358376-56-4

Basic information

• Product Name: C₆₆H₁₀₇N₅O₁₂Si
• Synonyms: C₆₆H₁₀₇N₅O₁₂Si
• CAS NO: 358376-56-4
• Molecular Weight: 1190.69
• Mol File: 358376-56-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆₆H₁₀₇N₅O₁₂Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₆H₁₀₇N₅O₁₂Si(358376-56-4)
• EPA Substance Registry System: C₆₆H₁₀₇N₅O₁₂Si(358376-56-4)

Safety Data

• Hazardous Substances Data: 358376-56-4(Hazardous Substances Data)

Upstream product

• 358376-52-0 TBS-protected sanglifehrin A 
• 358376-53-1 C₆₆H₁₀₇N₅O₁₃Si 
• 187148-13-6 (-)-sanglifehrin A 
• 77377-52-7 N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide 
• 358376-55-3 C₇₃H₁₁₁N₅O₁₄SSi 

Relevant articles and documents

Synthesis of derivatives of the novel cyclophilin-binding immunosuppressant sanglifehrin A with reduced numbers of polar functions

The syntheses and the biological activities of 53-deoxo sanglifehrin A (2) and 61-deoxy octahydrosanglifehrin A (3) are described. Compound 2 shows intracellular cyclophilin (CyP)-binding and immunosuppressive activity in the mixed-lymphocyte reaction (MLR) similar to that of sanglifehrin A (1). Compound 3 is much less active in the MLR despite unchanged intracellular CyP-binding. This indicates that the 53-keto group is not necessary for immunosuppressive activity, while the 61 hydroxy group is required.