35838-58-5 Usage
Uses
Used in Pharmaceutical Industry:
ETAZOLATE is used as an antipsychotic agent for the treatment of various psychiatric disorders. Its ability to modulate specific signaling pathways in the brain makes it a promising candidate for the development of new antipsychotic medications.
ETAZOLATE is also used as an antidepressant for the treatment of depression. It has shown significant antidepressant-like activity in animal models, indicating its potential as a novel treatment option for patients suffering from this condition.
Additionally, ETAZOLATE's role as a phosphodiesterase 4 inhibitor suggests that it may have applications in other areas of medicine, such as the treatment of inflammatory diseases or cardiovascular conditions. Further research is needed to explore these potential applications and fully understand the compound's therapeutic potential.
Biological Activity
etazolate hydrochloride is a pde-4 inhibitor and selective gaba-a receptor modulator [3].pde-4 modulates the release of inflammatory mediators through camp-dependent and -independent mechanisms. selective targeting pde-4 is a novel therapeutic approach in the treatment of inflammation-associated respiratory diseases, such as asthma and copd (chronic obstructive pulmonary disease) [1].in rat neuronal cortical cells, etazolate hydrochloride (0.2 μm) induced sappα through the stimulation of the α-secretase pathway, and exerted a neuroprotective effect against aβ which was associated with sappα induction via the gaba-a receptor [2].in 159 alzheimer’s disease patients, etazolate hydrochloride in combination with one achei (acetycholinesterase inhibitor) was shown to be safe and generally well tolerated in the phase iia study over a 3-month treatment period [3].
Biochem/physiol Actions
Selective inhibitor of cAMP-specific phosphodiesterase.
references
[1] dastidar s g, rajagopal d, ray a. therapeutic benefit of pde4 inhibitors in inflammatory diseases.[j]. current opinion in investigational drugs, 2007, 8(5):364-72. [2] marcade m, bourdin j, loiseau n, et al. etazolate, a neuroprotective drug linking gaba(a) receptor pharmacology to amyloid precursor protein processing.[j]. journal of neurochemistry, 2008, 106(1):392-404.[3] vellas b; sol o; snyder pj; ousset pj; haddad r; maurin m; lemarié jc; désiré l; pando mp; eht0202/002 study group. eht0202 in alzheimer's disease: a 3-month, randomized, placebo-controlled, double-blind study.[j]. current alzheimer research, 2011, 8(2):203-12.
Check Digit Verification of cas no
The CAS Registry Mumber 35838-58-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,8,3 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 35838-58:
(7*3)+(6*5)+(5*8)+(4*3)+(3*8)+(2*5)+(1*8)=145
145 % 10 = 5
So 35838-58-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H19N5O2.ClH/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2;/h7-8H,5-6H2,1-4H3,(H,15,18);1H
