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Usage

Uses

Used in Neurological Research:
Trans-1-Benzyl-pyrrolidine-3,4-dicarboxylic acid is used as a research tool for studying the role of glutamate receptors in synaptic transmission and plasticity. Its ability to induce seizures and excitotoxicity in the brain makes it useful for investigating neurological disorders such as epilepsy and neurodegenerative diseases.
Used in Pharmaceutical Development:
Trans-1-Benzyl-pyrrolidine-3,4-dicarboxylic acid is used as a starting material for the development of drugs targeting neurological disorders. Its interaction with ionotropic glutamate receptors can provide insights into the development of therapeutic agents for conditions such as epilepsy, Huntington's disease, and Alzheimer's disease.

Upstream product

• 87813-05-6 dimethyl (3R,4R)-1-benzylpyrrolidine-3,4-dicarboxylate 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 87813-06-7 dimethyl 1-benzylpyrrolidine-3,4-dicarboxylate 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS

Compositions and methods for the treatment of bacterial infections include compounds containing dimers of cyclic heptapeptides conjugated to one or more monosaccharide or oligosaccharide moieties. In particular, compounds can be used in the treatment of bacterial infections caused by Gram-negative bacteria.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS

Compositions and methods for the treatment of bacterial infections include compounds containing dimers of cyclic heptapeptides. In particular, compounds can be used in the treatment of bacterial infections caused by Gram-negative bacteria.

Synthesis and biological activity of Δ-5,6-norcantharimides: importance of the 5,6-bridge

Cantharidin (1) and norcantharidin (2) are potent protein phosphatase 1 and 2A inhibitors that also display high levels of anticancer activity against a broad range of tumor cells lines. Surprisingly, Δ-5,6-ethyl norcantharidin (3, cis-tetrahydrofurano[3,4-c]furan-1,3-dione) displays neither phosphatase inhibition nor anticancer activity. This suggests that the 5,6-ethyl bridge is pivotal to both anti-cancer and protein phosphatase activity. Additionally bioisosteric replacement of the ethereal oxygen has no effect on biological activity nor does modification of the anhydride moiety. Unlike the parent norcantharidin, anhydride ring opening has no effect on either protein phosphatase inhibition or anti-cancer activity. Additionally, this work highlights the discovery of the octyl substituted, cis-5-benzyl-2-hexyltetrahydro-2H,3aH-pyrrolo[3,4-c]pyrrole-1,3-dione, 9p, and the octyl substituted, cis-octyltetrahydro-5H-furo[3,4-c]pyrrole-4,6-dione, 8p, as two new cytotoxic agents which are equipotent (9p) with, and more potent (8p) than norcantharidin. Crown Copyright