3585-62-4Relevant academic research and scientific papers
Synthesis method of carbonyl alpha-position monomethyl substituted compound
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Paragraph 0026-0029; 0039-0042; 0053-0057, (2022/01/12)
The invention discloses a synthesis method of a carbonyl alpha-position monomethyl substituted compound, thesynthesis method comprises the following steps: taking substituted phenylboronic acid and ethyl 2-bromoacrylate as raw materials, taking THF and water as solvents, reacting K2CO3 and a catalyst Pd (OAc) 2 under the protection of nitrogen, purifying to obtain an intermediate product, dissolving the intermediate product in a methanol solvent, performing catalytic hydrogenation, reacting at room temperature, filtering, and spin-drying the solvent to obtain the carbonyl alpha-position monomethyl substituted compound. According to the synthesis method of the carbonyl alpha-position monomethyl substituted compound, the target compound can be conveniently obtained, the toxicity of reagents participating in the reaction is small, and the reaction conditions are mild. Post-treatment is simple and safe, the product quality is good, and the method is suitable for large-scale production.
