35852-81-4

Basic information

• Product Name: 4-Chloro-1-methylpyrazole
• Synonyms: 4-CHLORO-1-METHYLPYRAZOLE;4-Chloro-1-methyl-1H-pyrazole
• CAS NO: 35852-81-4
• Molecular Formula: C₄H₅ClN₂
• Molecular Weight: 116.55
• Mol File: 35852-81-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 169 °C
• Flash Point: 56 °C
• Appearance: /
• Density: 1.26
• Vapor Pressure: 2.045mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Chloro-1-methylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-1-methylpyrazole(35852-81-4)
• EPA Substance Registry System: 4-Chloro-1-methylpyrazole(35852-81-4)

Safety Data

• RIDADR: 1993
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 35852-81-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H5ClN2/c1-7-3-4(5)2-6-7/h2-3H,1H3

Upstream product

• 930-36-9 1-methyl-1H-pyrazole 
• 15878-00-9 4-chloro-1H-pyrazole 
• 74-88-4 methyl iodide 

Downstream Products

• 84547-94-4 1-methyl-4-chloro-3-nitro-1H-pyrazole 
• 84547-95-5 1-methyl-5-nitro-4-chloropyrazole 
• 84547-96-6 4-chloro-1-methyl-3,5-dinitro-1H-pyrazole 
• 1252831-16-5 4-chloro-1-methyl-5-(2-fluorophenyl)pyrazole 
• 1252831-14-3 4-chloro-5-(4-chlorophenyl)-1-methyl-pyrazole 
• 1252831-38-1 4-chloro-5-(4-methoxyphenyl)-1-methyl-pyrazole 
• 1252831-08-5 4-chloro-5-(3-chlorophenyl)-1-methyl-pyrazole 
• 1252831-36-9 4-chloro-5-(3-methoxyphenyl)-1-methyl-pyrazole 
• 1252831-18-7 4-chloro-1-methyl-5-(3-fluorophenyl)pyrazole 
• 1252831-11-0 C₁₀H₈Cl₂N₂ 
• 1252831-24-5 3-(4-chloro-2-methyl-pyrazol-3-yl)benzonitrile 
• 1252831-32-5 4-chloro-1-methyl-5-(m-tolyl)pyrazole 
• 1252831-34-7 4-chloro-1-methyl-5-(p-tolyl)pyrazole 
• 1252831-30-3 4-chloro-1-methyl-5-(o-tolyl)pyrazole 

Relevant articles and documents

Direct C-H Alkenylation of Functionalized Pyrazoles

We have developed inter- and intramolecular C-H alkenylation reactions of pyrazoles. The catalyst, derived from Pd(OAc)2 and pyridine, enabled the oxidative alkenylation of pyrazoles containing a variety of functional groups at the C4 position.

Enzymatic Halogenation of Pyrazoles and Pyridine Derivatives

Pyrazole, 1-methylpyrazole and 3-methylpyrazole are chlorinated by the enzyme chloroperoxidase from Caldariomyces fumago, in the presence of potassium chloride and hydrogen peroxide at pH 2.7, yielding the corresponding 4-chloro derivatives in good yields.A 4H-pyrazole is proposed as an intermediate in this reaction. 2-Aminopyridine was converted regiospecifically by the same enzyme into 2-amino-3-chloropyridine, and 8-hydroxyquinoline gave its 5,7-dibromo-derivatives in very good yield when bromide ion was used as halide substrate.