358621-75-7

Downstream Products

• 1027565-02-1 1,2-O-benzylidene-9-oxo-10-acetyl-4α(20)-epoxy-5-mesyltaxicine I 
• 358621-69-9 2-benzoyl-9-oxo-10-acetyl-4α(20)-epoxy-5-mesyltaxicine I 
• 358621-70-2 7-deoxy-5⁽²⁰⁾-deoxy-5⁽²⁰⁾-sulfanyl-13-oxobaccatin III 
• 358621-71-3 7-deoxy-5⁽²⁰⁾-deoxy-5⁽²⁰⁾-sulfanylbaccatin III 
• 1054734-45-0 5⁽²⁰⁾-deoxy-5⁽²⁰⁾-sulfanyl-7-deoxy-13-[[(4S,5R)-2-(4-methoxyphenyl)-3-(tert-butyloxycarbonyl)-4-phenyl-1,3-oxazolidin-5-yl]carbonyl]baccatin III 

Relevant academic research and scientific papers

Semisynthesis of D-ring modified taxoids: Novel thia derivatives of docetaxel

Two novel 5(20)-thia analogues of docetaxel have been synthesized from 10-deacetylbaccatin III or taxine B and isotaxine B. The key step of these syntheses is the concomitant thietane ring formation and acetylation of the tertiary alcohol at C-4. Both compounds are less cytotoxic than docetaxel but have divergent activity on microtubule disassembly.