358742-91-3Relevant academic research and scientific papers
Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants
Jung, Young-Sik,Kang, Tae-Souk,Yoon, Joong-Ho,Joe, Bo-Young,Lim, Hee-Jong,Seong, Churl-Min,Park, Woo-Kyu,Kong, Jae-Yang,Cho, Jungsook,Park, No-Sang
, p. 2599 - 2602 (2007/10/03)
4-Hydroxyphenylacetic acid amides and 4-hydroxycinnamamides were synthesized and their antioxidant and neuroprotective activities were evaluated. Among the prepared compounds, 6f, 6g, 8b, and 9 exhibited potent inhibition of lipid peroxidation in rat brain homogenates, and marked DPPH radical scavenging activities. Furthermore, 6f, 6g, and 9 exhibited neuroprotective action against the oxidative damage induced by the exposure of primary cultured rat cortical cells to H2O2, xanthine/xanthine oxidase, or Fe2+/ascorbic acid. Based on these results, we found that 6f was the most potent antioxidant among the compounds tested.
Synthesis of 3-alkoxy-4-hydroxyphenylacetic acids from methyl 3-alkoxybenzoates
Jung,Kang,Lee,Seong,Ham,Park
, p. 455 - 462 (2007/10/03)
3-Alkoxy-4-hydroxyphenylacetic acids 4 were obtained from 3-alkoxyl-substituted methyl benzoates 1 by reductive alkylation, followed by allylic oxidation and hydrolysis.
