3589-73-9 Usage
Uses
Used in Pharmaceutical Industry:
6-Methoxyharmalan is used as a reactant for the preparation of TRPV1-dependent vasodilators, which are compounds that help in the regulation of blood vessel diameter and blood flow, potentially benefiting cardiovascular health.
Used in Autophagy-Associated Disorders Treatment:
6-Methoxyharmalan is used as a therapeutic agent for the treatment of autophagy-associated disorders. Autophagy is a cellular process that helps in the degradation and recycling of cellular components, and its dysregulation can lead to various diseases. This alkaloid may play a role in modulating autophagy pathways, thus offering potential therapeutic benefits for related conditions.
References
Cassady et al., Lioydia, 34, 161 (1971)
Check Digit Verification of cas no
The CAS Registry Mumber 3589-73-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,8 and 9 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3589-73:
(6*3)+(5*5)+(4*8)+(3*9)+(2*7)+(1*3)=119
119 % 10 = 9
So 3589-73-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H14N2O/c1-8-13-10(5-6-14-8)11-7-9(16-2)3-4-12(11)15-13/h3-4,7,15H,5-6H2,1-2H3
3589-73-9Relevant academic research and scientific papers
Synthesis of 1-Substituted-2,3,4,9-tetrahydro-(2-oxopropyl)-1H-pyridoindoles and their Base-catalyzed Rearrangements to N-ethyl>acetamides
Bobowski, George
, p. 267 - 272 (2007/10/02)
The condensation of 1H-indole-3-ethanamines, 1, with 2,4-pentanediones, 2, gave enamines 3.Acid catalyzed ring closure of 3 gave 1-(1-substituted-2,3,4,9-tetrahydro-1-(2-oxopropyl)-1H-pyridoindoles 4.Subsequent N-acetylation yielded 5 which sequentially produced 2,3-disubstituted indoles 6 and 7 resulting from C-N bond cleavage after treatment with sodium alkoxide in ethanol.Controlled catalytic hydrogenation of the latter gave saturated derivatives 8 and 9.
