358974-27-3Relevant academic research and scientific papers
Probing the importance of the hemilabile site of bis(phosphine) monoxide ligands in the copper-catalyzed addition of diethylzinc to N-phosphinoylimines: Discovery of new effective chiral ligands
Bonnaventure, Isabelle,Charette, Andre B.
, p. 6330 - 6340 (2008/12/22)
(Chemical Equation Presented) The hemilabile ligand Me-DuPHOS(O) 2 has proven to be a successful ligand for the copper-catalyzed addition of diethylzinc to N-phosphinoylimines. The corresponding α-chiral amines were obtained in high yields (80-98%) and enantiomeric ratios (19.0:1 to 99.0:1 er). Furthermore, this Cu?2 catalytic system has been shown to be effective in the addition of diethylzinc to nitroalkenes and in the reduction of β,β-disubstituted vinyl phenyl sulfones. This paper describes a general structure/selectivity study in which the three ligand subunits (chiral phospholane-linker-labile coordinating group (Z)) are systematically modified and tested in the copper-catalyzed addition of diethylzinc to the N-phosphinoylimine 1 derived from benzaldehyde. This study led to the discovery of a new class of effective chiral ligands that combine a chiral phospholane unit and an achiral phosphine oxide.
Efficient asymmetric hydrogenation with rhodium complexes of C 1-symmetric 2,5-dimethylphospholane-diphenylphosphines
Basra, Sandeep,De Vries, Johannes G.,Hyett, David J.,Harrison, Gayle,Heslop, Katie M.,Orpen, A. Guy,Pringle, Paul G.,Von Der Luehe, Karl
, p. 1901 - 1905 (2007/10/03)
The unsymmetrical, optically active ligands 1,2-C6H 4(pph2)((R,R)-2,5-dimethylphospholanyl) (1a) and the new 1,1′-Fe(C5H4)2(PPh 2)((R,R)-2,5-dimethylphospholanyl) (1b) form compl
