35898-26-1

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 50-89-5 thymidine 
• 65-71-4 2,4-dihydroxy-5-methylpyrimidine 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 51255-17-5 1-O-methyl-2-deoxy-D-ribofuranoside 
• 78137-96-9 1-O-acetyl-3-O-benzyl-2-deoxy-5-O-(4-methylbenzoyl)-D-erythro-pentofuranose 
• 78137-88-9 methyl 3-O-benzyl-2-deoxy-5-O-(4-methylbenzoyl)-D-erythro-pentofuranoside 
• 78138-12-2 4-Methyl-benzoic acid (2R,3S)-3-benzyloxy-5-chloro-tetrahydro-furan-2-ylmethyl ester 
• 676598-19-9 methyl 2-deoxy-5-O-(4-methylbenzoyl)-D-erythro-pentofuranoside 
• 78138-04-2 1-<3-O-benzyl-2-deoxy-5-O-(4-methylbenzoyl)-α-D-erythro-pentofuranosyl>thymine 

Downstream Products

• 197719-57-6 4-Methyl-benzoic acid (2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 83467-48-5 1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 130277-32-6 ((2R,3S)-3-(tert-butyldiphenylsilyloxy)-2,3-dihydrofuran-2-yl)methanol 
• 4449-43-8 α-deoxythymidine 
• 197719-60-1 3'-TBDPS-5'-p-Tol-thymidine 

Relevant academic research and scientific papers

Non-standard nucleobases implementing the isocytidine and isoguanosine hydrogen bonding patterns

This invention provides compositions of matter that, when incorporated into an oligonucleotide, present to a complementary strand in a Watson-Crick pairing geometry a pattern of hydrogen bonds that is different from the pattern presented by adenine, guani

Facile preparation of protected furanoid glycals from thymidine

The synthesis of O-silyl- and O-acyl-protected furanose glycals from free thymidine was investigated. The method of glycal formation reported by Pedersen et al. was successfully expanded to include 5-ester (toluoyl) protected glycals as well as various combinations of 5'-ester and 3- and 5- tert-butyldimethylsilyl and tert-butyldiphenylsilyl protection. Gram quantities of furanoid glycals can be prepared in a few days in two-four steps in overall yields ranging from 17 to 80%.

STEREOCHEMICAL CONTROL AS A FUNCTION OF PROTECTING-GROUP PARTICIPATION IN 2-DEOXY-D-ERYTHRO-PENTOFURANOSYL NUCLEOSIDES

Possible features controlling the anomeric ratios in the synthesis of the antiviral antibiotic dihydro-5-azathymidine have been examined.Replacement of the 3- and 5-(4-methylbenzoyl) protecting groups in 2-deoxy-D-erythro-pentofuranosyl chloride by benzyl