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(14R)-Grayanotox-10(20)-ene-3β,5,6β,11α,14,16-hexol, commonly known as grayanotoxin or andromedotoxin, is a potent natural toxin derived from plants in the Ericaceae family, such as rhododendrons, azaleas, and mountain laurels. This toxin specifically targets voltage-gated sodium channels, causing their prolonged opening and leading to the depolarization of nerve cells. The effects of grayanotoxin can manifest as dizziness, weakness, low blood pressure, and heart arrhythmias. Consumption of plants containing this toxin can result in "mad honey poisoning," a condition reported in areas where honey is sourced from nectar of grayanotoxin-containing plants. Historically, its toxic properties have been exploited for use in poison-tipped arrows and spears in some cultures.

35928-08-6

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35928-08-6 Usage

Uses

Used in Pharmaceutical Research:
(14R)-Grayanotox-10(20)-ene-3β,5,6β,11α,14,16-hexol is utilized in pharmaceutical research for its ability to modulate voltage-gated sodium channels. This makes it a valuable tool in studying the function and dysfunction of these channels in various neurological conditions and potentially developing treatments for channelopathies.
Used in Toxicological Studies:
As a potent neurotoxin, (14R)-Grayanotox-10(20)-ene-3β,5,6β,11α,14,16-hexol is used in toxicological studies to understand the mechanisms of action of toxins on the nervous system. This can aid in the development of antidotes and treatments for poisoning incidents.
Used in Ethnobotanical Education:
(14R)-Grayanotox-10(20)-ene-3β,5,6β,11α,14,16-hexol serves as a cautionary example in ethnobotanical education, illustrating the potential dangers of consuming plants without proper knowledge of their toxic properties. It highlights the importance of traditional knowledge and scientific research in the safe use of plant resources.
Used in Forensic Analysis:
Due to its historical use as a poison, (14R)-Grayanotox-10(20)-ene-3β,5,6β,11α,14,16-hexol is relevant in forensic analysis for the detection and identification of toxic substances in cases of suspected poisoning or bioterrorism.
Used in Environmental Monitoring:
(14R)-Grayanotox-10(20)-ene-3β,5,6β,11α,14,16-hexol can be monitored in the environment, particularly in regions where plants containing this toxin are prevalent, to ensure the safety of local flora and fauna, as well as human populations that may come into contact with these plants or their products, such as honey.

Check Digit Verification of cas no

The CAS Registry Mumber 35928-08-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,9,2 and 8 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 35928-08:
(7*3)+(6*5)+(5*9)+(4*2)+(3*8)+(2*0)+(1*8)=136
136 % 10 = 6
So 35928-08-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O6/c1-9-11-6-13(21)17(2,3)20(11,26)15(23)5-10-8-18(4,25)12-7-14(22)19(9,10)16(12)24/h10-16,21-26H,1,5-8H2,2-4H3

35928-08-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Grayanotoxin XII

1.2 Other means of identification

Product number -
Other names 1,1,8-trimethyl-4-methylidenedodecahydro-4a,7-methanocyclopenta[b]heptalene-2,5,8,11,11a,12(1h)-hexol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:35928-08-6 SDS

35928-08-6Upstream product

35928-08-6Downstream Products

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