359436-62-7

Basic information

• Product Name: 11-Maleimidoundecanoic Acid Hydrazide
• Synonyms: 2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-undecanoic Acid Hydrazide;11-Maleimidoundecanoic acid hydrazide (KMUH);11-Maleimidoundecanoic acid hydrazide-HCl (KMUH)
• CAS NO: 359436-62-7
• Molecular Formula: C15H25N3O3
• Molecular Weight: 295.38
• Product Categories: Maleimide Derivatives;Cross Linking Reagents;MTS & Sulfhydryl Active Reagents;Maleimide Derivatives, MTS & Sulfhydryl Active Reagents, Cross Linking Reagents
• Mol File: 359436-62-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 105-107°C
• Boiling Point: 503.2°C at 760 mmHg
• Flash Point: 258.1°C
• Appearance: /
• Density: 1.128g/cm³
• Vapor Pressure: 2.97E-10mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: -20°C Freezer
• CAS DataBase Reference: 11-Maleimidoundecanoic Acid Hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 11-Maleimidoundecanoic Acid Hydrazide(359436-62-7)
• EPA Substance Registry System: 11-Maleimidoundecanoic Acid Hydrazide(359436-62-7)

Safety Data

• Hazardous Substances Data: 359436-62-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 359436-62-7 differently. You can refer to the following data:
1. A sulfhydryl and carbonyl reactive heterobifunctional crosslinking reagent. Spacer Arm: 19.0 Angstroms
2. A sulfhydryl and carbonyl reactive heterobifunctional crosslinking reagent.Spacer Arm: 19.0 Angstroms

InChI:InChI=1/C15H25N3O3/c16-17-13(19)9-7-5-3-1-2-4-6-8-12-18-14(20)10-11-15(18)21/h10-11H,1-9,12,16H2,(H,17,19)

Upstream product

• 57079-01-3 11-(2,5-dioxopyrrol-1-yl)undecanoic acid 
• 280136-41-6 11-maleimidoundecanoyl chloride 

Relevant articles and documents

Preparation method of heterobifunctional protein cross-linking agent having hydrazide structure

The invention relates to the technical field of preparation of compounds, in particular to a preparation method of a heterobifunctional protein cross-linking agent having a hydrazide structure. The method comprises the following steps: enabling maleimide alkyl acid, i.e., a compound A to be subjected to a heating reaction under the action of a solvent and sulfoxide chloride so as to enable a carboxyl group in the structure of the compound A to be converted into acyl chloride; mixing obtained maleimide alkyl acyl chloride with a solvent and various types of compounds B, and performing an acylation reaction under the action of organic or inorganic alkali so as to generate a compound C; and removing a protecting group at the hydrazine end of the compound C under the action of a solvent and acid or alkali so as to obtain maleimide alkyl hydrazide having the hydrazide structure. According to the method involved in the invention, the cheap and readily available maleimide alkyl acid, as a starting raw material, is prepared into the maleimide alkyl hydrazide by three steps of reactions; the yield of a synthetic route is higher; a product is suitable for the research and development and production of an antibody-drug conjugate; and a synthesis method is simple and convenient to operate, safe and controllable, and suitable for industrial production.