359601-60-8

Upstream product

• 4397-53-9 p-benzyloxybenzaldehyde 
• 118-48-9 isatoic anhydride 
• 28144-70-9 anthranilic acid amide 

Relevant academic research and scientific papers

Synthesis of some novel 2-aryl-substituted 2,3-dihydroquinazolin-4(1 H)-ones under solvent-free conditions using MCM-41-SO3H as a highly efficient sulfonic acid

MCM-41-SO3H, ordered mesoporous silica material MCM-41 with covalently anchored sulfonic acid groups located inside the mesochannels, was used as an acid catalyst for the rapid and green synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives

Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics

Diphtheria toxin-like ADP-ribosyltransferases catalyse a posttranslational modification, ADP-ribosylation and form a protein family of 17 members in humans. Two of the family members, tankyrases 1 and 2, are involved in several cellular processes including mitosis and Wnt/β-catenin signalling pathway. They are often over-expressed in cancer cells and have been linked with the survival of cancer cells making them potential therapeutic targets. In this study, we identified nine tankyrase inhibitors through virtual and in vitro screening. Crystal structures of tankyrase 2 with the compounds showed that they bind to the nicotinamide binding site of the catalytic domain. Based on the co-crystal structures we designed and synthesized a series of tetrahydroquinazolin-4-one and pyridopyrimidin-4-one analogs and were subsequently able to improve the potency of a hit compound almost 100-fold (from 11 μM to 150 nM). The most potent compounds were selective towards tankyrases over a panel of other human ARTD enzymes. They also inhibited Wnt/β-catenin pathway in a cell-based reporter assay demonstrating the potential usefulness of the identified new scaffolds for further development.

An efficient one-pot solvent-free synthesis of 2,3-dihydroquinazoline-4(1H) -ones via Al/Al2O3 nanoparticles

An efficient one-pot, solvent-free method is reported for the synthesis of 2-phenyl-2,3-dihydroquinazoline-4(1H)-one as well as its o-Cl, o-OMe, m-Br, m-NO2, p-OH, p-NO2, p-CN, p-PhCH2O, p-Cl, p-F, p-Br, p-Me, and o,m-dich

Click reaction: Highly efficient synthesis of 2,3-dihydroquinazolin-4(1H)- ones

In this work, condensation reaction of 2-aminobenzamide with various alkyl, aryl, and alicyclic aldehydes or ketones to 2,3-dihydroquinazolin-4(1H)-one derivatives in the presence of a catalytic amount of ammonium chloride in ethanol at room temperature is described. This reaction can be classified as a click chemical synthesis because of its high yields, short reaction times, and green and efficient reaction medium. Copyright Taylor & Francis Group, LLC.

Synthesis of new 2-aryl substituted 2,3-dihydroquinazoline-4(1H)-ones under solvent-free conditions, using molecular iodine as a mild and efficient catalyst

A simple, inexpensive, and efficient one-pot synthesis of 2,3-dihydroquinazoline-4(1H)-one derivatives under solvent-free conditions using a catalytic amount of iodine with excellent product yields is reported. This methodology provides easy, quantitative