359623-74-8 Usage
Uses
Used in Organic Synthesis:
1-(4-nitrophenyl)-2,5-diphenyl-1H-pyrrole-3-carbaldehyde is used as a building block in organic synthesis for the creation of various biologically active molecules due to its complex molecular structure and reactivity.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(4-nitrophenyl)-2,5-diphenyl-1H-pyrrole-3-carbaldehyde is utilized as an intermediate for the preparation of pharmaceuticals, taking advantage of its unique structural features to develop new drugs.
Used in Drug Discovery and Development:
1-(4-nitrophenyl)-2,5-diphenyl-1H-pyrrole-3-carbaldehyde is also used as a target for drug discovery and development because of the potential bioactivity conferred by the nitro group in its structure, which may lead to the creation of novel therapeutic agents.
Used in the Chemical Industry:
1-(4-nitrophenyl)-2,5-diphenyl-1H-pyrrole-3-carbaldehyde serves as an important intermediate in the chemical industry, where it is used in the synthesis of a range of products, from pharmaceuticals to other specialty chemicals that require its specific structural attributes.
Check Digit Verification of cas no
The CAS Registry Mumber 359623-74-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,9,6,2 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 359623-74:
(8*3)+(7*5)+(6*9)+(5*6)+(4*2)+(3*3)+(2*7)+(1*4)=178
178 % 10 = 8
So 359623-74-8 is a valid CAS Registry Number.
359623-74-8Relevant academic research and scientific papers
Blackburn, Tim J.,Ahmed, Shafiq,Coxon, Christopher R.,Liu, Junfeng,Lu, Xiaohong,Golding, Bernard T.,Griffin, Roger J.,Hutton, Claire,Newell, David R.,Ojo, Stephen,Watson, Anna F.,Zaytzev, Andrey,Zhao, Yan,Lunec, John,Hardcastle, Ian R.
, p. 1297 - 1304 (2013)
Screening identified 2-(3-((4,6-dioxo-2-thioxotetrahydropyrimidin-5(2H)- ylidene)methyl)-2,5-dimethyl-1H-pyrrol-1-yl)-4,5,6,7-tetrahydrobenzo[b] thiophene-3-carbonitrile as an MDM2-p53 inhibitor (IC50 = 12.3 μM). MDM2-p53 and MDMX-p53 activity was seen for 5-((1-(4-chlorophenyl)-2,5- diphenyl-1H-pyrrol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione (MDM2 IC50 = 0.11 μM; MDMX IC50 = 4.2 μM) and 5-((1-(4-nitrophenyl)-2,5-diphenyl-1H-pyrrol-3-yl)methylene)pyrimidine-2,4,6(1H, 3H,5H)-trione (MDM2 IC50 = 0.15 μM; MDMX IC50 = 4.2 μM), and cellular activity consistent with p53 activation in MDM2 amplified cells. Further SAR studies demonstrated the requirement for the triarylpyrrole moiety for MDMX-p53 activity but not for MDM2-p53 inhibition. The Royal Society of Chemistry.
