(1) It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.
white to light yellow crystal powde
A chiral derivative of Camphor. Used in the preparation of a chiral recognition polymer that is used in the chiral separation of amino acids. A catalyst in direct animation of α-branched aldehydes (in
cluding important biological molecules such as α-Me phenylglycine) with near perfect enantioselectivity.
Camphor sulfonic acid is obtained from camphor and sulfuric acid by irradiation.
This method involves:
1) Adding the camphor and acetic anhydride to the pot.
2) Mixing it and making it dissolved.
3) Dripping sulfuric acid after cooling. And the reaction should be maintained at 44-45 °C for 48 hours. Then cool it to 6-7 °C.
4) Crystallizing, filtrating, washing with a small amount of acetic acid crystals, and dry it to get camphor sulfonic acid.
ChEBI: The R enantiomer of camphorsulfonic acid.
It is a kind of prismatic crystals and its melting point is 193-195 ° C (decompose). It is Insoluble in ether and slightly soluble in glacial acetic acid and ethyl acetate. And it is and moisture in wet air.
It forms prisms from AcOH or EtOAc, and is deliquescent in moist air. Store it in tightly stoppered bottles. The NH4 salt forms needles from H2O  D ±20.5o (c 5, H2O). [Burgess & Lowry J Chem Soc 127 279 1925, Marsi et al. J Am Chem Soc [ 78 3063 1956.] The RS-acid recrystallises from AcOH. [60g of (±)-acid in 60mL of AcOH at 105o gave 40g of crystals has m 202-203o [Bartlett & Knox Org Synth 45 12 1965.] [Beilstein 11 IV 642.]
Camphor sulfonic acid includes L-camphor sulfonic acid, D-camphor sulfonic acid and racemic camphor sulfonic acid these three isomers.
It is a kind of white columnar crystals with the melting point of 193°C (decomposition). [α]D20+24° (water). It is Slightly soluble in ethanol, insoluble in ether, soluble in sodium hydroxide and sodium carbonate solution. L-camphor sulfonic acid could be produced from reaction between camphor, sulfuric acid and acetic anhydride.It has a lot of functions such as exciting the respiratory center, the vascular movement center and myocardium. Its sodium salt plays pharmaceutical role in medicine.
Camphor sulfonic acid sodium salt is a kind of white crystalline powder. It is odorless and tastes bitter and then sweet. It is easily absorb moisture and easily dissolve in the water and hot ethanol. So it should be shading confined preservation. it can Directly excite the medulla oblongata respiratory center and vascular movement center, and quicken and deepen the breath, rise the blood pressure; it also can directly excite the myocardium and strength the contraction of cardiac muscle as well as could increase the output.
It is applied the treatment of infectious disease, as well as the disease like central inhibition of poisoning caused by respiratory depression, fatigue, high fever, poisoning, heat stroke and other acute heart failure.