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359630-61-8

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359630-61-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 359630-61-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,9,6,3 and 0 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 359630-61:
(8*3)+(7*5)+(6*9)+(5*6)+(4*3)+(3*0)+(2*6)+(1*1)=168
168 % 10 = 8
So 359630-61-8 is a valid CAS Registry Number.

359630-61-8Downstream Products

359630-61-8Relevant articles and documents

A new synthetic agent with potent but selective cytotoxic activity against cancer

Cholody, Wieslaw M.,Kosakowska-Cholody, Teresa,Hollingshead, Melinda G.,Hariprakasha, Humcha K.,Michejda, Christopher J.

, p. 4474 - 4481 (2005)

The synthesis of novel unsymmetrical bifunctional antitumor agents was accomplished by linking an imidazoacridone moiety to another polycyclic heteroaromatic moiety via linkers of various length and rigidity. These compounds bind to cellular DNA, but it is hypothesized that biological effects become manifested when the drug-DNA complexes interact with critical DNA binding proteins that are involved in repair and transcription. The most promising compound of the series, 4ad (WMC79), consists of an imidazoacridone linked to a 3-nitronaphthalimide moiety via a 1,4-dipropanopiperazine linker. It was found to be potently, but selectively, cytotoxic against colon cancers (GI 50 = 0.5 nM, LC50 = 32 nM) and leukemias (GI50 = 3.5 nM, LC50 = 33 nM). Compound 4ad, which appears to be a candidate for further development as an anticancer drug, kills sensitive cells by induction of apoptosis. It also showed significant in vivo activity against HCT-116 colon cancer xenografts in nude mice. Other compounds in the series also exhibited antitumor properties, but they were significantly lower than that of 4ad.

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