35970-03-7

Basic information

• Product Name: 2-(2-nitrobenzyl)-1H-isoindole-1,3(2H)-dione
• CAS NO: 35970-03-7
• Molecular Formula: C₁₅H₁₀N₂O₄
• Molecular Weight: 282.2509
• Mol File: 35970-03-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 460.2°C at 760 mmHg
• Flash Point: 232.1°C
• Density: 1.464g/cm³
• Vapor Pressure: 1.19E-08mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: 2-(2-nitrobenzyl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-nitrobenzyl)-1H-isoindole-1,3(2H)-dione(35970-03-7)
• EPA Substance Registry System: 2-(2-nitrobenzyl)-1H-isoindole-1,3(2H)-dione(35970-03-7)

Safety Data

• Hazardous Substances Data: 35970-03-7(Hazardous Substances Data)

Usage

Organic compound

A compound primarily composed of carbon, hydrogen, and other elements, often containing complex structures and functional groups.

Nitrobenzene group

A functional group consisting of a benzene ring with a nitro group (-NO2) attached to it, which imparts specific chemical properties to the molecule.

Isoindole-1,3-dione group

A heterocyclic aromatic ring system with a fused carbonyl group (C=O) at positions 1 and 3, contributing to the compound's unique structure and properties.

Commonly used in organic synthesis

This compound is frequently employed as a building block or intermediate in the synthesis of more complex organic molecules.

Potential applications in medicinal chemistry

Due to its unique structure, 2-(2-nitrobenzyl)-1H-isoindole-1,3(2H)-dione may have uses in the development of pharmaceuticals or other bioactive compounds.

Hazardous if ingested or inhaled

This compound can pose health risks if it is swallowed or breathed in, so proper safety precautions should be taken when handling it.

Storage requirements

Cool, dry place away from heat and open flames
To maintain stability and prevent decomposition, 2-(2-nitrobenzyl)-1H-isoindole-1,3(2H)-dione should be stored in a cool, dry environment, away from sources of heat or open flames.

Upstream product

• 612-23-7 2-nitrobenzyl chloride 
• 1074-82-4 potassium phtalimide 
• 85-44-9 phthalic anhydride 
• 1904-78-5 2-nitrobenzylamine 
• 136918-14-4 phthalimide 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 24835-08-3 2-nitrobenzylamine hydrochloride 
• 2142-01-0 N-benzylphthalimide 
• 7697-37-2 nitric acid 

Downstream Products

• 2224-75-1 3-(4-fluorophenyl)isoindolin-1-one 
• 37459-58-8 3-(4-Methoxyphenyl)-isoindolin-1-on 
• 835-18-7 3-phenyl-2,3-dihydro-isoindol-1-one 

Relevant articles and documents

DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS

A method of identifying compounds as direct inhibitors of Keap1-Nrf2 interaction through high-throughput screening and lead development. The direct inhibitors of Keap1-Nrf2 interaction are more specific and free of various undesirable effects than existing indirect inhibitors, and are potential drug candidates of chemopreventive and therapeutic agents for treatment of various diseases or conditions involving oxidative stress and/or inflammation, including but not limited to cancers, diabetes, Alzheimer's, and Parkinson's. Novel compounds are identified and methods of preventing or treating diseases or conditions related to Keap1-Nrf2 interaction activity by use of the novel compounds identified or compositions containing such compounds are also disclosed.

DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS

A method of identifying compounds as direct inhibitors of Keap1-Nrf2 interaction through high-throughput screening and lead development. The direct inhibitors of Keap1-Nrf2 interaction are more specific and free of various undesirable effects than existing indirect inhibitors, and are potential drug candidates of chemopreventive and therapeutic agents for treatment of various diseases or conditions involving oxidative stress and/or inflammation, including but not limited to cancers, diabetes, Alzheimer's, and Parkinson's. Novel compounds are identified and methods of preventing or treating diseases or conditions related to Keapl-Nrf2 interaction activity by use of the novel compounds identified or compositions containing such compounds are also disclosed.

Di-μ-hydroxy-bis(N,N,N′,N′-tetramethylenediamine)-copper(II) chloride [Cu(OH)·TMEDA]2Cl2: An efficient, practical catalyst for benzylation and allylation of amides

An efficient protocol for the benzylation or allylation of amides using the corresponding benzyl or allyl chlorides as electrophiles under basic conditions with commercially available 5 mol % of [Cu(OH)TMEDA]2Cl2 as catalyst was developed. Under these conditions, unprotected amino acids were benzylated without any racemization.