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4-HYDRAZINO-6-PHENYLTHIENO[2,3-D]PYRIMIDINE, also known as AG-120, is a chemical compound that has demonstrated potential as a targeted therapy for the treatment of certain types of cancer, particularly those associated with mutations in the isocitrate dehydrogenase 1 (IDH1) gene. It functions by inhibiting the mutated IDH1 enzyme, which is involved in the production of the oncometabolite 2-hydroxyglutarate (2-HG), a molecule implicated in driving tumorigenesis. AG-120 has been the subject of preclinical and clinical studies, showing promising results in the treatment of acute myeloid leukemia (AML) and other solid tumors. Ongoing research and clinical trials are aimed at fully exploring the therapeutic potential of 4-HYDRAZINO-6-PHENYLTHIENO[2,3-D]PYRIMIDINE in cancer therapy.

35970-80-0

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35970-80-0 Usage

Uses

Used in Oncology:
4-HYDRAZINO-6-PHENYLTHIENO[2,3-D]PYRIMIDINE is used as a targeted therapy for the treatment of cancers with IDH1 mutations, such as acute myeloid leukemia (AML) and other solid tumors. It serves as an enzyme inhibitor, specifically targeting the mutated IDH1 enzyme to reduce the production of the oncometabolite 2-hydroxyglutarate (2-HG), thereby potentially slowing or stopping tumor growth and progression.
Used in Pharmaceutical Research and Development:
In the pharmaceutical industry, 4-HYDRAZINO-6-PHENYLTHIENO[2,3-D]PYRIMIDINE is used as a subject of preclinical and clinical studies to evaluate its safety, efficacy, and potential side effects. These studies are crucial for understanding the compound's role in cancer therapy and for determining the optimal dosages and treatment regimens for patients.
Used in Drug Development for Precision Medicine:
4-HYDRAZINO-6-PHENYLTHIENO[2,3-D]PYRIMIDINE is utilized in the development of precision medicine approaches, where treatments are tailored to the specific genetic mutations present in a patient's cancer. This targeted approach aims to increase the effectiveness of treatment while minimizing side effects compared to traditional chemotherapy.

Check Digit Verification of cas no

The CAS Registry Mumber 35970-80-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,9,7 and 0 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 35970-80:
(7*3)+(6*5)+(5*9)+(4*7)+(3*0)+(2*8)+(1*0)=140
140 % 10 = 0
So 35970-80-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H10N4S/c13-16-11-9-6-10(8-4-2-1-3-5-8)17-12(9)15-7-14-11/h1-7H,13H2,(H,14,15,16)

35970-80-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (6-phenylthieno[2,3-d]pyrimidin-4-yl)hydrazine

1.2 Other means of identification

Product number -
Other names 4-hydrazino-6-phenyl-thieno[2,3-d]pyrimidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:35970-80-0 SDS

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