35971-70-1Relevant academic research and scientific papers
Efficient large-scale synthesis of CAT811, a potent calpain inhibitor of interest in the treatment of cataracts
Jones, Matthew A.,Coxon, James M.,McNabb, Stephen B.,Mehrtens, Janna M.,Alexander, Nathan A.,Jones, Seth,Chen, Hongyuan,Buisan, Clmence,Abell, Andrew D.
experimental part, p. 671 - 675 (2010/01/16)
A high-yielding, short, and scalable synthesis of a potent calpain 2 inhibitor (CAT811) is reported. The key step in the sequence involves an intramolecular macrocyclization of a 6-iodonorleucine residue to the side chain of tyrosine. CSIRO 2009.
Potentiometric and Spectrophotometric Study of the Co-ordiantion Compounds formed between Cooper(II) and Dipeptides containing Tyrosine
Hefford, Robert J. W.,Pettit, Leslie D.
, p. 1331 - 1335 (2007/10/02)
Co-ordiantion compounds formed between L-tyrosylglycine (H2L), L-tyrosyl-L-leucine, L-tyrosyl-D-leucine, glycyltyrosine, L-leucyl-L-tyrosine, and L-tyrosineamide a H+ and Cu2+ have been studied potentiometrically at 25 deg C and l=0.10 mol dm-3 (K(NO3)).In addition to the expected complex compounds (Cu(HL))+, (CuL), (Cu(H-1L))-, and (Cu(H-2L))2-, and (Cu(HL2))-, a binuclear complex, ((Cu(H-1L))2)2-, was found to form in the pH region 8-10.5 with tyrosylglycine and tyrosyl-D/L-leucine (giving a green solution) but was absent when tyrosine was the terminal carboxyl of the dipeptide.Spectrophotometric titrations showed this dimer to involve cooper(II)-phenolate oxygen bonding.A structure for the dimer is described which explains the absence of a comparable dimer with glycyl- and leucyl-tyrosine, and the stereoselectivity found with the tyrosyl-D/L-leucine diastereomers.
