35975-30-5

Usage

Uses

Used in Pharmaceutical Industry:
Piperazine-2,6-dione hydrochloride is used as a synthetic intermediate for the preparation of anti-inflammatory and antitumor compounds. Its versatile chemical structure allows for the development of new drugs with potential therapeutic benefits in treating inflammation and cancer.
Used in Analgesic Compounds:
Piperazine-2,6-dione hydrochloride is also used in the synthesis of 4-succinamoyl-piperazine-2,6-dione derivatives, which possess analgesic properties. These compounds can be utilized in the development of pain-relieving medications, providing relief for patients suffering from various types of pain.

Upstream product

• 35975-17-8 4-benzyl-piperazine-2,6-dione 
• 165824-59-9 4-formyl-2,6-piperazinedione 

Downstream Products

• 254991-22-5 4-(4-nitro-benzenesulfonyl)-piperazine-2,6-dione 
• 1293368-07-6 4-[4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl]piperazine-2,6-dione 
• 937054-87-0 4-{3-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-2,6-piperazinedione 
• 501127-89-5 4-tert-butoxycarbonylpiperazine-2,6-dione 
• 254991-24-7 4-benzenesulfonyl-piperazine-2,6-dione 

Relevant academic research and scientific papers

NOVEL ACYLPIPERAZINONES AND THEIR USE AS PHARMACEUTICALS

The invention relates to novel acylpiperazinone compounds, to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.

PYRAZOLE DERIVATIVES

A compound represented by formula (I): (wherein Ar1 represents a phenyl group which may have 1 to 3 substituents, or a non-substituted 5- or 6-membered aromatic heterocyclic group; Ar2 represents (i) a non-substituted phenyl group, (ii) a phenyl group which has been substituted by a lower alkyl group having 1 to 3 groups or atoms selected from among a carbamoyl group, an amino group, a hydroxyl group, a lower alkoxy group, and a halogen atom, or (iii) a 5- or 6-membered nitrogen-containing aromatic heterocyclic group which has been substituted by 1 to 3 groups or atoms selected from among a lower alkyl group, a lower alkynyl group, a lower alkanoyl group, a carbamoyl group, a cyano group, an amino group, a hydroxyl group, a lower alkoxy group, and a halogen atom; and X represents a group represented by formula (II): (wherein the ring structure represents a 4- to 7-membered heterocyclic group which may have, in addition to the nitrogen atom shown in formula (II), one heteroatom selected from among nitrogen, oxygen, and sulfur, and which may be substituted by 1 to 4 groups or atoms selected from among a lower alkyl group, a carbamoyl group, an amino group, a hydroxyl group, a lower alkoxy group, an oxo group, a lower alkanoyl group, a lower alkylsulfonyl group, and a halogen atom)), a salt thereof, a solvate of the compound or the salt, and a drug.

METHOD FOR THE PREPARATIVE OF PIPERAZINEDIONE-2,6

A method has been developed for the preparation of piperazinedione-2,6.It consists in the cyclization of iminodiacetic acid with ammonium formate.The dependance of the yield of the final product on the reaction temperature, the ratio of components, and the choice of the solvent has been investigated.