35975-93-0Relevant academic research and scientific papers
Investigating the role of metal chelation in HIV-1 integrase strand transfer inhibitors
Bacchi, Alessia,Carcelli, Mauro,Compari, Carlotta,Fisicaro, Emilia,Pala, Nicolino,Rispoli, Gabriele,Rogolino, Dominga,Sanchez, Tino W.,Sechi, Mario,Sinisi, Valentina,Neamati, Nouri
, p. 8407 - 8420 (2011)
HIV-1 integrase (IN) has been validated as an attractive target for the treatment of HIV/AIDS. Several studies have confirmed that the metal binding function is a crucial feature in many of the reported IN inhibitors. To provide new insights on the metal
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics
Sato, Motohide,Motomura, Takahisa,Aramaki, Hisateru,Matsuda, Takashi,Yamashita, Masaki,Ito, Yoshiharu,Kawakami, Hiroshi,Matsuzaki, Yuji,Watanabe, Wataru,Yamataka, Kazunobu,Ikeda, Satoru,Kodama, Eiichi,Matsuoka, Masao,Shinkai, Hisashi
, p. 1506 - 1508 (2007/10/03)
The viral enzyme integrase is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents a remaining target for antiretroviral drugs. Here, we describe the modification of a quinolone antibiotic to produce the novel integr
