359781-80-9Relevant academic research and scientific papers
Lysine sulfonamides as novel HIV-protease inhibitors: Nε-disubstituted ureas
Stranix, Brent R.,Sauve, Gilles,Bouzide, Abderrahim,Cote, Alexandre,Sevigny, Guy,Yelle, Jocelyn,Perron, Valerie
, p. 3971 - 3974 (2007/10/03)
A series of lysine sulfonamide analogues bearing a Nε-benzylic ureas was synthesized using both solution-phase and solid-phase approaches. A novel synthetic route of Nα-(alkyl)-Nα-(sulfonamides)lysinol using α-amino-caprolactam was developed. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type HIV virus.
Urea derivatives as HIV aspartyl protease inhibitors
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, (2008/06/13)
The present invention provides HIV aspartyl protease inhibitors of the formula: and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein n is 3 or 4, Y is O, S, NH or N—CN, wherein Cx may be,
Lysine sulfonamides as novel HIV-Protease inhibitors: Optimization of the Nε-acyl-phenyl spacer
Stranix, Brent R.,Sauve, Gilles,Bouzide, Abderrahim,Cote, Alexandre,Sevigny, Guy,Yelle, Jocelyn
, p. 4289 - 4292 (2007/10/03)
A series of Nα-isobutyl-Nα-arylsulfonamido-(Nε acyl) lysine and lysinol derivatives were prepared and evaluated as inhibitors of HIV protease and wild type virus. A simple original synthesis was devised to form Nα-(arylsulfonamide)-Nα-isobutyl lysine, whi
HIV protease inhibitors based on amino acid derivatives
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, (2008/06/13)
A compound selected from the group consisting of a compound of formula I 1a compound of formula II 2and when the compound of formula I and II comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.
Amino acid derivatives as HIV aspartyl protease inhibitors
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, (2008/06/13)
The present invention relates to a class of amino acid derivatives with HIV aspartyl protease inhibitory properties.
