359782-07-3Relevant academic research and scientific papers
Lysine sulfonamides as novel HIV-Protease inhibitors: Optimization of the Nε-acyl-phenyl spacer
Stranix, Brent R.,Sauve, Gilles,Bouzide, Abderrahim,Cote, Alexandre,Sevigny, Guy,Yelle, Jocelyn
, p. 4289 - 4292 (2007/10/03)
A series of Nα-isobutyl-Nα-arylsulfonamido-(Nε acyl) lysine and lysinol derivatives were prepared and evaluated as inhibitors of HIV protease and wild type virus. A simple original synthesis was devised to form Nα-(arylsulfonamide)-Nα-isobutyl lysine, whi
