35984-40-8Relevant academic research and scientific papers
Synthesis and tyrosinase inhibition activity of trans-stilbene derivatives
Ismail, Tabasum,Shafi, Syed,Srinivas, Jada,Sarkar, Dhiman,Qurishi, Yasrib,Khazir, Jabeena,Alam, Mohammad Sarwar,Kumar, Halmuthur Mahabalarao Sampath
, p. 97 - 102 (2016)
Synthesis of a focussed library of trans-stilbene compounds through Wittig and other base catalysed condensation reactions is presented. The synthesized stilbenes were screened for their inhibitory potential against murine tyrosinase activity to explore the structure activity relationship (SAR). Presence of electron withdrawing group (-CN) at the double bond and hydroxyl group or halogen atom especially at para-position on the aromatic rings was found to significantly elevate the inhibitory activity. Among all the compounds screened, compounds 2, 6, 8, 10, 11, 15 and 21 were found to exhibit appreciable inhibitory activity. Compound 21 ((E)-2,3-bis(4-Hydroxyphenyl)acryonitrile) was found to be the most active with an IC50 value of 5.06 μM which is less than half of the value 10.78 μM observed for resveratrol (common standard used in murine tyrosinase activity studies) under similar conditions. The results obtained from the present study reveal structural/functional group sensitivity for the tyrosinase inhibitory activity of stilbenoid moieties and are expected to be very helpful for the design and synthesis of novel, selective and effective tyrosinase inhibitors.
Benzocyclobutenoacenaphthylene stilbenes. 1. Synthesis and thermal properties
Buchacher, Petra,Helgeson, Roger,Wudl, Fred
, p. 9698 - 9702 (1998)
In this paper the synthesis and characterization of a new class of molecules based on 6b,10b-dihydrobenzo[j]cyclobut[a]acenaphthylene (DBCA) with potentially interesting optical and electronic properties are described. The mentioned compounds contain one
N-Arylated pyridinium salts having reactive groups
Yamaguchi, Isao,Higashi, Hideo,Shigesue, Sachiko,Shingai, Saki,Sato, Moriyuki
, p. 7778 - 7781 (2008/03/11)
The pyridinium salts having reactive amine and/or pyridyl groups were obtained by the reaction using Zincke salts. Optical properties and anion exchange behavior of the obtained pyridinium salts were investigated.
