359878-47-0

Basic information

• Product Name: N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine
• Synonyms: N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine;4-(4-Fluorobenzylamino)-1-methylpiperidine;N-(4-fluorobenzyl)-1-Methylpiperidin-4-aMine;N-(4-flurobenzyl)-1-methylpiperidin-4-Amine
• CAS NO: 359878-47-0
• Molecular Formula: C₁₃H₁₉FN₂
• Molecular Weight: 222
• EINECS: 1592732-453-0
• Mol File: 359878-47-0.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 305℃
• Flash Point: 138℃
• Appearance: /
• Density: 1.07
• Vapor Pressure: 0.000852mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 9.38±0.20(Predicted)
• CAS DataBase Reference: N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine(359878-47-0)
• EPA Substance Registry System: N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine(359878-47-0)

Safety Data

• Hazardous Substances Data: 359878-47-0(Hazardous Substances Data)

Usage

Uses

N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine is a piperidine derivative and can be used as a pharmaceutical intermediate.

InChI:InChI=1/C13H19FN2/c1-16-8-6-13(7-9-16)15-10-11-2-4-12(14)5-3-11/h2-5,13,15H,6-10H2,1H3

Upstream product

• 41838-46-4 4-Amino-1-methylpiperidine 
• 459-57-4 4-fluorobenzaldehyde 
• 1445-73-4 1-Methyl-4-piperidone 
• 140-75-0 para-fluorobenzylamine 

Downstream Products

• 706779-91-1 N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide 
• 1080491-31-1 N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N’-(4-(2-methylpropyloxy)phenylmethyl)carbamide tartaric acid 
• 1080491-34-4 1-(4-fluorobenzyl)-3-(4-(1,1-d2-isobutoxy)benzyl)-1-(1-methylpiperidin-4-yl)urea 
• 706782-28-7 Pimavanserin tartrate 
• 955997-87-2 N,N'-bis(4-isobutoxybenzyl)urea 

Relevant articles and documents

Novel derivatives of urea and use thereof

The present invention relates to a novel urea derivative compound and 5HT thereof. 2A The present invention relates to the use of antagonists as antagonists for the prevention or treatment of neuropsychiatric disorders, degenerative brain diseases, propagated disorders and/or metabolic diseases.

Application of pimavanserin in preparation of antitumor drugs

The invention relates to application of pimavanserin in preparation of antitumor drugs, belongs to the technical field of medicines, and particularly relates to novel application of pimavanserin in preparation of antitumor drugs. The structural formula of the pimavanserin is shown in the formula I. The biological activity test of the compound shows that the compound has antitumor activity and is a novel antitumor drug.

PROCESS FOR THE MANUFACTURING OF PIMAVANSERIN

The present invention relates to a new process for manufacturing 1-(4-fluorobenzyl)-3-(4-iso-butoxyphenyl)-1-(1-methylpiperidin-4-yl)urea, with the INN name pimavanserin, and its hemitartrate salt.