35989-02-7

Usage

Uses

Used in Research and Pharmaceutical Industries:
2-(3-BROMOPYRIDIN-5-YL)PYRIDINE is utilized as a key intermediate in the synthesis of various organic compounds and drugs. Its unique structure and reactivity contribute to the development of new molecules with potential therapeutic applications.
Used in Materials Science:
Due to its structural properties, 2-(3-BROMOPYRIDIN-5-YL)PYRIDINE may have applications in materials science, where it could be incorporated into the design of new materials with specific properties.
Used in Medicinal Chemistry:
In medicinal chemistry, 2-(3-BROMOPYRIDIN-5-YL)PYRIDINE is employed as a building block for the development of new drugs, potentially leading to the discovery of novel therapeutic agents.
It is crucial to handle 2-(3-BROMOPYRIDIN-5-YL)PYRIDINE with care due to its potential hazards and toxicity, ensuring safety in research and industrial applications.

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 81745-83-7 2-pyridylzinc chloride 
• 109-04-6 2-bromo-pyridine 

Relevant academic research and scientific papers

Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts

Herein are reported ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages, including 2,4′-, 2,3′-, and 2,2′-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes. The methodology was successfully applied to the synthesis of the natural products caerulomycin A and E.

Sulfur(IV)-Mediated Unsymmetrical Heterocycle Cross-Couplings

Despite the tremendous utilities of metal-mediated cross-couplings in modern organic chemistry, coupling reactions involving nitrogenous heteroarenes remain a challenging undertaking – coordination of Lewis basic atoms into metal centers often necessitate elevated temperature, high catalyst loading, etc. Herein, we report a sulfur (IV) mediated cross-coupling amendable for the efficient synthesis of heteroaromatic substrates. Addition of heteroaryl nucleophiles to a simple, readily-accessible alkyl sulfinyl (IV) chloride allows formation of a trigonal bipyramidal sulfurane intermediate. Reductive elimination therefrom provides bis-heteroaryl products in a practical and efficient fashion.

6-O-carbamate-11,12-lacto-ketolide antimicrobials

6-O-Carbamate-11,12-lacto-ketolide antimicrobials of the formula: wherein R1, R2, R3 R7, and R8 are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.