3599-32-4 Usage
Description
Sodium 2-(7-(3,3-dimethyl-1-(4-sulfonatobutyl)benz(e)indolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolinium, also known as IC-Green (Akorn), is a tricarbocyanine type of dye with infrared absorbing properties. It is characterized by its green to brown crystals or crystalline powder appearance.
Uses
Used in Diagnostic Aids:
Sodium 2-(7-(3,3-dimethyl-1-(4-sulfonatobutyl)benz(e)indolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolinium is used as a diagnostic aid for various medical applications, including blood volume determination, cardiac output, and hepatic function. Its infrared absorbing properties make it a valuable tool in these areas.
Used in Infrared Photography:
In the field of photography, this dye is utilized in infrared photography, where its unique properties allow for enhanced imaging capabilities.
Used in Preparation of Wratten Filters:
Sodium 2-(7-(3,3-dimethyl-1-(4-sulfonatobutyl)benz(e)indolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolinium is also used in the preparation of Wratten filters, which are color filters used in photography and cinematography to enhance or modify the colors captured by the camera.
Used in Dyes and Metabolites:
Sodium 2-(7-(3,3-dimethyl-1-(4-sulfonatobutyl)benz(e)indolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolinium is employed in the production of dyes and metabolites, where its unique chemical properties contribute to the development of new and improved products in these industries.
Safety Profile
Poison by intravenous
route. When heated to decomposition it
emits very toxic fumes of SOx, Na2O, and
NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 3599-32-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,9 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3599-32:
(6*3)+(5*5)+(4*9)+(3*9)+(2*3)+(1*2)=114
114 % 10 = 4
So 3599-32-4 is a valid CAS Registry Number.
InChI:InChI=1/C43H48N2O6S2.Na/c1-42(2)36-26-24-32-18-10-12-20-34(32)40(36)44(28-14-16-30-52(46,47)48)38(42)22-8-6-5-7-9-23-39-43(3,4)37-27-25-33-19-11-13-21-35(33)41(37)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1/rC43H47N2NaO6S2/c1-42(2)36-26-24-32-18-10-12-20-34(32)40(36)44(28-14-16-30-53(47,48)49)38(42)22-8-6-5-7-9-23-39-43(3,4)37-27-25-33-19-11-13-21-35(33)41(37)45(39)29-15-17-31-54(50,51)52-46/h5-13,18-27H,14-17,28-31H2,1-4H3
3599-32-4Relevant articles and documents
Deuterated Indocyanine Green (ICG) with Extended Aqueous Storage Shelf-Life: Chemical and Clinical Implications
Li, Dong-Hao,Smith, Bradley D.
, p. 14535 - 14542 (2021)
Indocyanine Green (ICG) is a clinically approved near-infrared fluorescent dye that is used extensively for various imaging and diagnostic procedures. One drawback with ICG is its instability in water, which means that reconstituted clinical doses have to be used very shortly after preparation. Two deuterated versions of ICG were prepared with deuterium atoms on the heptamethine chain, and the spectral, physiochemical, and photostability properties were quantified. A notable mechanistic finding is that self-aggregation of ICG in water strongly favors dye degradation by a photochemical oxidative dimerization reaction that gives a nonfluorescent product. Storage stability studies showed that replacement of C?H with C?D decreased the dimerization rate constant by a factor of 3.1, and it is likely that many medical and preclinical procedures will benefit from the longer shelf-lives of these two deuterated ICG dyes. The discovery that ICG self-aggregation promotes photoinduced electron transfer can be exploited as a new paradigm for next-generation photodynamic therapies.
Indocyanine green, and preparation method and application thereof
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Paragraph 0030-0032; 0037; 0038, (2017/07/01)
The invention provides indocyanine green, and a preparation method and application thereof. The indocyanine green is shown as formula 1. The method is performed according to a path recorded in the specification. According to the path, 2, 3, 3-trimethyl-4, 5-benzoindoles, 1, 4-butyl sultone and 2-glutarate diphenylamine hydrochloride, as raw materials, are compounded into the indocyanine green shown as the target compound formula 1. The method has a short compounding path, simple process and high yield, does not need heavy metal catalysis, and meets requirements of 'green chemical' development.