3599-75-5Relevant academic research and scientific papers
TRIAZINE COMPOUNDS AND COMPOSITIONS THEREOF AND METHODS FOR TREATING MALARIA AND CHEMOPROPHYLAXIS
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Paragraph 0111; 0112, (2014/10/15)
Disclosed herein are triazine compounds and methods of making and using thereof to treat malaria, provide chemoprophylaxis, and/or treat or inhibit infection by one or more Plasmodium spp.
Antimalarial Activity of 2-(Substituted amino)-4,6-bis(trichloromethyl)-1,3,5-triazines and N-(Chlorophenyl)-N'-guanidines
Werbel, Leslie M.,Elslager, Edward F.,Hess, Carolyn,Hutt, Marland P.
, p. 1943 - 1948 (2007/10/02)
A series of 2-amino>-4,6-bis(trichloromethyl)-1,3,5-triazines (III) and N-(4-chlorophenyl)-N'-amino>-6-(trichloromethyl)-1,3,5-triazin-2-yl>guanidines (IV) were prepared from 2,4,6-tris(trichloromethyl)-1,3,5-triazine and 2-chloro-4,6-bis(trichloromethyl)-1,3,5-triazine.Compounds of type III showed modest antimalarial activity while XIa with the camoquin side chain was more potent.Analogues of type IV broadly exhibited modest antimalarial activity.
