3599-89-1

Basic information

• Product Name: propionamidine hydrochloride
• Synonyms: PROPANAMIDINE HYDROCHLORIDE;propionamidine acetic acid;Propioamidine hydrochloride;Propanamidine hydrochloride 97%;Propionamidine hydrochloride, Propanimidamide hydrochloride;PropaniMidaMide,Monohydrochloride (9CI)
• CAS NO: 3599-89-1
• Molecular Formula: C₃H₈N₂*ClH
• Molecular Weight: 108.56996
• EINECS: 222-753-6
• Mol File: 3599-89-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 298.5 °C
• Boiling Point: 90.8°Cat760mmHg
• Flash Point: 8.7°C
• Appearance: /
• Density: 0.99g/cm³
• Vapor Pressure: 55.3mmHg at 25°C
• Refractive Index: 1.462
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: propionamidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: propionamidine hydrochloride(3599-89-1)
• EPA Substance Registry System: propionamidine hydrochloride(3599-89-1)

Safety Data

• Hazardous Substances Data: 3599-89-1(Hazardous Substances Data)

Usage

Uses

Propioamidine Hydrochloride acts as a reagent in the synthetic preparation of guanidine.

InChI:InChI=1/C3H8N2/c1-2-3(4)5/h2H2,1H3,(H3,4,5)

Upstream product

• 40546-35-8 ethyl propanimidate hydrochloride 
• 39739-45-2 methylpropioimidate hydrochloride 
• 107-12-0 propiononitrile 

Downstream Products

• 100064-22-0 N,N,N'-tris-(4-nitro-benzenesulfenyl)-propionamidine 
• 75074-97-4 2-ethyl-4-methyl-pyrimidine 
• 18344-51-9 2-amino-3-methyl-5-nitropyridine 
• 79899-27-7 2-ethyl-5-nitropyrimidine 
• 3599-60-8 2,4-Diaethyl-s-triazin 
• 91391-86-5 2-ethyl-4-phenyl-pyrimidine 
• 3709-98-6 2-ethylpyrimidine-4,6-diol 
• 1891-90-3 p-trifluoromethylbenzamide 
• 35370-26-4 N-phenyl-propionamidine 
• 1570495-00-9 5-(1-benzyl-5-ethyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole 
• 1216193-88-2 3-ethyl-5-(p-tolyl)-4H-1,2,4-triazole 
• 3213-92-1 3-ethyl-5-phenyl-4H-1,2,4-triazole 
• 1399178-20-1 4-(1-(4-cyclobutyl-5-(2-ethyl-1H-imidazol-5-yl)-2-methylbenzoyl)piperidin-4-yl)benzonitrile 

Relevant articles and documents

Synthesis and evaluation of hedgehog signaling inhibitor with novel core system

As we previously reported, N-methylpyrrolo[3,2-c]pyridine derivatives 1 (TAK-441) was discovered as a clinical candidate of hedgehog (Hh) signaling inhibitor by modification of the upper part. We next focused on modification of the lower part including core skeletons to discover new Hh signaling inhibitors with novel core rings. Efforts to find novel chemotypes by using X-ray single crystal structure analysis led to some potent Hh signaling inhibitors (2c, 2d, 2e, 2f) with novel core ring systems, which had benzamide moiety at the 5-position as a key component for potent activity. The suppression of Gli1 expression with these new Hh signaling inhibitors were weaker than that of compound 1 (TAK-441) because of low pharmacokinetic property. We recognized again TAK-441 is a good compound as clinical candidate with good structural and pharmacokinetic advantages.

Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect

A series of ethylene bis-imidazoles was synthesized via a novel microwave-mediated synthesis. Biological testing on eight isozymes of carbonic anhydrase (CA) present in the human brain revealed compounds with nanomolar potency against CA VA and CA VII, also displaying excellent selectivity against other CA isozymes present in this organ. the Partner Organisations 2014.

FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF

The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof. Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.