35991-75-4

Basic information

• Product Name: PYRIDINE,3,5-BIS(BROMOMETHYL)-
• Synonyms: PYRIDINE,3,5-BIS(BROMOMETHYL)-;3,5-bis(bromomethyl)pyridine
• CAS NO: 35991-75-4
• Molecular Formula: C7H7Br2N
• Molecular Weight: 264.95
• Mol File: 35991-75-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 315.1±32.0 °C(Predicted)
• Appearance: /
• Density: 1.870±0.06 g/cm3(Predicted)
• PKA: 3.42±0.20(Predicted)
• CAS DataBase Reference: PYRIDINE,3,5-BIS(BROMOMETHYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE,3,5-BIS(BROMOMETHYL)-(35991-75-4)
• EPA Substance Registry System: PYRIDINE,3,5-BIS(BROMOMETHYL)-(35991-75-4)

Safety Data

• Hazardous Substances Data: 35991-75-4(Hazardous Substances Data)

Usage

General Description

PYRIDINE,3,5-BIS(BROMOMETHYL)- is a chemical compound that belongs to the class of pyridines, which are organic compounds containing a pyridine ring, a six-membered ring with five carbon atoms and one nitrogen atom. In this specific compound, there are two bromomethyl groups attached at the 3 and 5 positions of the pyridine ring. It is commonly used as a reagent in organic synthesis, specifically in the production of pharmaceuticals and agrochemicals. The presence of the bromine atoms makes it a useful building block for the synthesis of complex organic molecules. Additionally, it is used in the manufacturing of pesticides and herbicides. However, as with any chemical, proper handling and safety precautions should be followed to mitigate potential hazards associated with its use.

Upstream product

• 4591-55-3 dimethyl pyridine-3,5-dicarboxylate 
• 499-81-0 3,5-Pyridinedicarboxylic acid 
• 4591-56-4 diethyl 3,5-pyridinedicarboxylate 
• 21636-51-1 3,5-bis(hydroxymethyl)pyridine 

Relevant articles and documents

NOVEL BENZODIAZEPINE DERIVATIVES AND USES THEREOF

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

The flexibility-complementarity dichotomy in receptor-ligand interactions

Synthetic supramolecular complexes provide an opportunity for quantitative systematic exploration of the relationship between chemical structure and molecular recognition phenomena. A family of closely related zinc porphyrin-pyridine complexes was used to examine the interplay of conformational flexibility and geometric complementarity in determining the selectivity of molecular recognition events. The association constants of 48 zinc porphyrin-pyridine complexes were measured in two different solvents, toluene and 1,1,2,2-tetrachloroethane (TCE). These association constants were used to construct 32 chemical double mutant cycles to dissect the free energy contributions of intramolecular H-bonds between the phenol side arms of the porphyrins and the ester or amide side arms of the pyridine ligands. Effective molarities (EM) for the intramolecular interactions were determined by comparison with the corresponding intermolecular H-bonding interactions. The values of EM do not depend on the solvent and are practically identical for amide and ester H-bond acceptors located at the same site on the ligand framework. However, there are variations of an order of magnitude in EM depending on the flexibility of the linker used to connect the H-bond acceptors to the pyridine ligands. Rigid aromatic linkers give values of EM that are an order of magnitude higher than the values of EM for the corresponding ester linkers, which have one additional torsional degree of freedom. However, the most flexible ether linkers give values of EM that are also higher than the values of EM for the corresponding ester linkers, which have one less torsional degree of freedom. Although the penalty for conformational restriction on binding is higher for the more flexible ether linkers, this flexibility allows optimization of the geometric complementarity of the ligand for the receptor, so there is a trade off between preorganization and fit.

Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition

Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition.