360069-39-2Relevant academic research and scientific papers
Aromatic inhibitors of dehydroquinate synthase: Synthesis, evaluation and implications for gallic acid biosynthesis
Chandran, Sunil S.,Frost
, p. 1493 - 1496 (2001)
The role of the active site metal in determining binding to 3-dehydroquinate synthase has been examined. Protocatechuic acid, catechol, and derivatives of these aromatics were synthesized that shared the common element of an ortho dihydroxylated benzene ring. Inhibition constants were determined for each aromatic as well as the variation of this inhibition as a function of whether Co+2 or Zn+2 was the active site metal ion.
