36052-28-5Relevant academic research and scientific papers
HYDROXY ALKYL SUBSTITUTED 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS
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Page 166-167, (2008/06/13)
The present invention is directed to novel hydroxy alkyl substituted 1, 3, 8-triazaspiro[4.5]decan-4-one derivatives of the general formula: wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.
The use of nafion-h to promote epoxide cyclizations
Taylor, Stephen K.,Dickinson, Michael G.,May, Scott A.,Pickering, Dacia A.,Sadek, Paul C.
, p. 1133 - 1136 (2007/10/03)
Nafion-H is shown to be an effective promoter of epoxide cyclizations to aromatic positions. The reactions can be done by passing a solution of the epoxide through a column packed with Nafion-H, or by stirring a mixture of the compound with the acidic pro
Friedel-crafts cyclialkylations of some epoxides. 2. Stereospecificity, substituent, product, and kinetic studies
Taylor, Stephen K.,Davisson, Mark E.,Hissom Jr., B. Rolf,Brown, Sandra L.,Pristach, Holle A.,Schramm, Scott B.,Harvey, Suzanne M.
, p. 425 - 429 (2007/10/02)
The relative facility of the cyclialkylation of several arylalkyl epoxides was investigated. Stereochemical studies on the cyclialkylation of cis- and trans-2,3-epoxy-5-phenylpentane establish that the stereospecificity of ring formation is as high as 97%
