360560-82-3Relevant academic research and scientific papers
Diastereocontrolled reduction of cyclic β-enaminones. A new diastereoselective route to 2,6-disubstituted piperidines
Fréville, Stéphanie,Delbecq, Philippe,Thuy, Vu Moc,Petit, Huguette,Célérier, Jean Pierre,Lhommet, Gérard
, p. 4609 - 4611 (2007/10/03)
A new diastereoselective synthesis of 2,6-disubstituted piperidinic alkaloids is presented. Three natural compounds, the (-)-pinidinone 1a, the (+)-dihydropinidine 1b and the (-)-pinidinol 1c were prepared from optically pure (6R)-6-methylpiperidin-2-one 2. This method is based on the chemo- and diastereocontrolled reductions of an exocyclic β-enamino ketone.
