360579-29-9

Upstream product

• 27784-76-5 tert-butyl diethylphosphonoacetate 
• 228267-22-9 (2R,4R)-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-(4-formylphenyl)pyrrolidine 
• 228267-21-8 (3R)-4-tert-butoxycarbonylamino-3-tert-butyldimethylsiloxy-1-(4-dimethoxymethylphenyl)butanol 

Downstream Products

• 312297-46-4 (2R,4R)-1-tert-butoxycarbonyl-4-hydroxy-2-[4-[(S)-1-[(R)-N-benzyl-N-(α-methylbenzyl)amino]-2-tert-butoxycarbonylethyl]phenyl]pyrrolidine 
• 312297-45-3 (2R,4R)-1-tert-butoxycarbonyl-2-[4-[(E)-2-(tert-butoxycarbonyl)vinyl]phenyl]-4-hydroxypyrrolidine 

Relevant academic research and scientific papers

Stereoselective synthesis of a broad spectrum 1β-methylcarbapenem, J-114,870

An ultra-broad spectrum carbapenem, J-114,870 (1), was synthesized from the corresponding C-2 side chain and 1β-methylcarbapenem enolphosphate. Synthesis of the C-2 side chain was accomplished by installation of the benzene part to (4R)-hydroxy-2-pyrrolidone 3, affording 2-phenylpyrrolidine 8a, and asymmetric Michael addition of chiral amine to α,β-unsaturated ester derived from 8a. (C) 2000 Elsevier Science Ltd.