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36070-84-5

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36070-84-5 Usage

Description

5-Bromopyrazine-2-carboxamide is a white to off-white crystalline powder that belongs to the class of pyrazine derivatives. It is a chemical compound primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Due to its ability to interact with biological systems, it has potential use in the development of new drugs and is also utilized in the research and development of new chemical compounds. However, it is crucial to handle 5-Bromopyrazine-2-carboxamide with caution to mitigate potential health and environmental risks.

Uses

Used in Pharmaceutical Industry:
5-Bromopyrazine-2-carboxamide is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its interaction with biological systems makes it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 5-Bromopyrazine-2-carboxamide serves as an intermediate in the production of agrochemicals, contributing to the development of effective crop protection agents.
Used in Research and Development:
5-Bromopyrazine-2-carboxamide is utilized in research and development for the creation of new chemical compounds, expanding the scope of chemical knowledge and innovation.

Check Digit Verification of cas no

The CAS Registry Mumber 36070-84-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,0,7 and 0 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 36070-84:
(7*3)+(6*6)+(5*0)+(4*7)+(3*0)+(2*8)+(1*4)=105
105 % 10 = 5
So 36070-84-5 is a valid CAS Registry Number.

36070-84-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-bromopyrazine-2-carboxamide

1.2 Other means of identification

Product number -
Other names 5-Brom-2-pyrazincarboxamid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:36070-84-5 SDS

36070-84-5Downstream Products

36070-84-5Relevant articles and documents

Structure-Guided Modification of Heterocyclic Antagonists of the P2Y14 Receptor

Yu, Jinha,Ciancetta, Antonella,Dudas, Steven,Duca, Sierra,Lottermoser, Justine,Jacobson, Kenneth A.

supporting information, p. 4860 - 4882 (2018/06/20)

The P2Y14 receptor (P2Y14R) mediates inflammatory activity by activating neutrophil motility, but few classes of antagonists are known. We have explored the structure-activity relationship of a 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-5-(aryl)benzoic acid antagonist scaffold, assisted by docking and molecular dynamics (MD) simulation at a P2Y14R homology model. A computational pipeline using the High Throughput MD Python environment guided the analogue design. Selection of candidates was based upon ligand-protein shape and complementarity and the persistence of ligand-protein interactions over time. Predictions of a favorable substitution of a 5-phenyl group with thiophene and an insertion of a three-methylene spacer between the 5-aromatic and alkyl amino moieties were largely consistent with empirical results. The substitution of a key carboxylate group on the core phenyl ring with tetrazole or truncation of the 5-aryl group reduced affinity. The most potent antagonists, using a fluorescent assay, were a primary 3-aminopropyl congener 20 (MRS4458) and phenyl p-carboxamide 30 (MRS4478).

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