360771-95-5

Upstream product

• 360771-93-3 3-benzyloxy-4-hydroxy-17,17-ethylenedioxy-1,3,5⁽¹⁰⁾-estratrien-6-one 
• 360771-91-1 3,4-dihydroxy-17,17-ethylenedioxy-1,3,5⁽¹⁰⁾-estratrien-6-one diacetate 
• 360771-92-2 3,4-dihydroxy-17,17-ethylenedioxy-1,3,5⁽¹⁰⁾-estratrien-6-one 
• 100-44-7 benzyl chloride 
• 360771-94-4 3-benzyloxy-4-hydroxy-17,17-ethylenedioxy-1,3,5⁽¹⁰⁾-estratrien-6-one acetate 

Downstream Products

• 88016-83-5 3-benzyloxy-4-methoxy-1,3,5⁽¹⁰⁾-estratrien-17-one 
• 58562-33-7 4-methoxyestrone 
• 85359-12-2 3-benzyloxy-4-hydroxy-1,3,5⁽¹⁰⁾-estratrien-17-one 

Relevant academic research and scientific papers

Selective synthesis of 4-methoxyestrogen from 4-hydroxyestrogen

The introduction of an oxygen atom into the C-6 position of 4-hydroxyestrogen allowed for the selective methylation of the two phenolic hydroxyl groups. When the 6-oxo derivative of 4-hydroxyestrone was benzylated in ethanol, only the 3-monobenzyl ether was obtained without formation of the 4-monobenzyl ether. Moreover, the 6-carbonyl group was further reduced to methylene almost quantitatively in the reaction of 4-acetoxy-6-oxoestrone 3-benzyl ether derivative with sodium borohydride. Therefore, 4-methoxyestrogen was synthesized by essentially combining these two reactions. Copyright