360772-90-3Relevant academic research and scientific papers
Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition
Thorarensen, Atli,Douglas Jr., Martin R.,Rohrer, Douglas C.,Vosters, Anne F.,Yem, Anthony W.,Marshall, Vincent D.,Lynn, Janet C.,Bohanon, Michael J.,Tomich, Paul K.,Zurenko, Gary E.,Sweeney, Michael T.,Jensen, Randy M.,Nielsen, James W.,Seest, Eric P.,Dolak, Lester A.
, p. 1355 - 1358 (2007/10/03)
Peptidyl deformylase (PDF) is a metallo protease that catalyzes the removal of a formyl group from the N-termini of prokaryotic prepared polypeptides, an essential step in bacterial protein synthesis. Screening of our compound collection using Staphylococ
