36078-98-5Relevant academic research and scientific papers
Design and synthesis of novel metalloproteinase inhibitors
Nakatani, Shingo,Ikura, Masahiro,Yamamoto, Shingo,Nishita, Yoshitaka,Itadani, Satoshi,Habashita, Hiromu,Sugiura, Tsuneyuki,Ogawa, Koji,Ohno, Hiroyuki,Takahashi, Kanji,Nakai, Hisao,Toda, Masaaki
, p. 5402 - 5422 (2007/10/03)
A series of N-benzoyl 4-aminobutyric acid hydroxamate analogs were synthesized and evaluated as matrix metalloproteinase inhibitors. Synthetic work was focused on the chemical modification of the 4-aminobutyric acid part using easily available starting materials. As such, chemical modification was carried out using commercially available starting materials such as 4-aminobutyric acid, (+)- and (-)-malic acid, and d- and l-glutamic acid derivatives. Among the compounds tested, N-[4-(benzofuran-2-yl)benzoyl] 4-amino-4S-hydroxymethylbutyric acid hydroxamates derived from l-glutamic acid demonstrated more potent inhibitory activity against MMP-2 and MMP-9 compared with the corresponding 2S-hydroxy analogs or 3S-hydroxy analogs, respectively, which were derived from (-)-malic acid. Structure-activity relationship study is presented.
Melanin concentrating hormone antagonist
-
Page/Page column 77-78, (2010/11/23)
A melanin-concentrating hormone antagonist which comprises a compound of the formula: wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms;Y is a bond or a spacer having a main chain of 1
Aminobutyric acid derivatives
-
, (2008/06/13)
An aminobutyric acid derivative of the formula (I): (wherein all symbols are as defined in the specification) and salt thereof. salt thereof. The compounds of the formula (I) possess an inhibitory activity on matrix metalloproteinase and are useful for prevention and/or treatment of diseases, for example, rheumatoid diseases, arthrosteitis, unusual bone resorption, osteoporosis, periodontitis, interstitial nephritis, arteriosclerosis, pulmonary emphysema, cirrhosis, cornea injury, metastasis of, invasion of or growth of tumor cells, autoimmune disease (e.g. Crohn's disease, Sjogren's syndrome), disease caused by vascular emigration or infiltration of leukocytes, arterialization, multiple sclerosis, aorta aneurysm, endometriosis.
A colored dendrimer as a new soluble support in organic synthesis. Part 1: Suzuki reaction
Zhang, Jidong,Aszodi, Jozsef,Chartier, Céline,L'Hermite, Nathalie,Weston, John
, p. 6683 - 6686 (2007/10/03)
A new strategy using a colored dendrimer as visible soluble support for organic synthesis has been developed. The efficiency of this new system has been demonstrated by the use of DRHMPA9-CH2OH as the support in a Suzuki coupling reaction. Due to the visibility of the support, following of the reaction has been rendered easier and the purification time of the crude product has been considerably shortened.
Development and Application of Organic Reagents for Analysis. VI. Synthesis and Fluorescence Spectral Properties of 2-(4-Substituted phenyl)benzofurans
Akiyama, Shuzo,Akimoto, Hiroyuki,Nakatsuji, Shin'ichi,Nakashima, Kenichiro
, p. 2192 - 2196 (2007/10/02)
A synthesis of fifteen kinds of 2-(4-substituted phenyl)benzofurans (4n) was carried out and their fluorescence spectral properties were investigated concerning their applicability as organic reagents for analyses.
Benzofuran derivatives
-
, (2008/06/13)
Novel benzofuran containing a benzimidazolyl group are obtained by reacting a benzofuran containing a carboxylic acid halide group with either an ortho-phenylene diamine or an ortho-nitro-aniline derivative, in the latter case reducing the nitro intermedi
