360787-67-3

Basic information

• Product Name: methyl 3-[(S)-α-methylbenzyl]-2-oxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate
• Synonyms: methyl 3-[(S)-α-methylbenzyl]-2-oxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate
• CAS NO: 360787-67-3
• Molecular Weight: 376.455
• Mol File: 360787-67-3.mol

Chemical Properties

• CAS DataBase Reference: methyl 3-[(S)-α-methylbenzyl]-2-oxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-[(S)-α-methylbenzyl]-2-oxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate(360787-67-3)
• EPA Substance Registry System: methyl 3-[(S)-α-methylbenzyl]-2-oxo-2,3,4,5,6,11-hexahydro-1H-azocino[4,5-b]indole-1-carboxylate(360787-67-3)

Safety Data

• Hazardous Substances Data: 360787-67-3(Hazardous Substances Data)

Upstream product

• 360787-65-1 dimethyl 3-[3-[N-(S)-α-methylbenzyl-N-tert-butoxycarbonylamino]propyl]indole-2-propanedioate 
• 360787-64-0 [3-(1H-indol-3-yl)-propyl]-(1-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 360787-62-8 3-(1H-indol-3-yl)-N-(1-phenyl-ethyl)-propionamide 
• 360787-63-9 3-[3-[((S)-α-methylbenzyl)amino]propyl]indole 
• 360788-02-9 3-(1H-indol-3-yl)propionaldehyde 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 830-96-6 Indole-3-propionic acid 
• 4414-76-0 1H-indole-3-propiononitrile 
• 120-72-9 indole 
• 360787-66-2 dimethyl 3-[3-[(S)-α-methylbenzylamino]propyl]indole-2-propanedioate 

Relevant articles and documents

Syntheses of 5a′-homo-vinblastine and congeners designed to establish structural determinants for isolation of atropisomers

The syntheses of 5a′-homo-vinblastine (3a) and its C-20′ methyl congener 62a were achieved. In contrast to vinblastine, these compounds did not allow isolation of atropisomers because of their lower conformational inversion barrier. However, annelation of a six-membered ring to the conformationally mobile D′-piperidine ring provided an isolated atropisomer 81a, which could be converted to its lower energy conformation 65a on heating. The 5a′-homo-vinblastine congeners 3a, 62a, and 65a showed vinblastine-like inhibition of tubulin polymerization and cytotoxicity to L1210 leukemia cells, albeit at lower potency for the latter activity, than that found with the corresponding compounds in the vinblastine series.