36099-25-9

Upstream product

• 1571-08-0 methyl 4-formylbenzoate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 3609-53-8 methyl 4-acetylbenzoate 
• 56893-25-5 methyl 4-(2-bromoacetyl)benzoate 
• 2181-42-2 trimethylsulphonium iodide 

Downstream Products

• 1571-08-0 methyl 4-formylbenzoate 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 920273-96-7 4-(1-hydroxy-2-methylamino-ethyl)-benzoic acid methyl ester 
• 1392467-25-2 4-[1-hydroxy-2-(2,2,2-trifluoroethoxy)ethyl]benzoic acid 
• 1392467-26-3 4-(2-hydroxy-1-(2,2,2-trifluoroethoxy)ethyl)benzoic acid 
• 46190-45-8 4-(2-hydroxyethyl)benzoic acid methyl ester 

Relevant academic research and scientific papers

MeOTf/KI-catalyzed efficient synthesis of 2-arylnaphthalenesviacyclodimerization of styrene oxides

The MeOTf/KI-catalyzed synthesis of 2-arylnaphthalene derivatives from aryl ethylene oxides in alcohol under ambient conditions is described. The present protocol has a higher atom efficiency and wider substrate applicability with excellent yields. The reaction proceeded using the aryl ethylene oxides to give 2-arylnaphthalenes either in homo-coupling or in cross-coupling. The reaction could also be carried out at the gram scale in minutes.

Dirhodium(II)-Mediated Alkene Epoxidation with Iodine(III) Oxidants

Dirhodium(II) complexes and iodine(III) oxidants have found useful applications in synthetic nitrene chemistry. In this study, the combination of the dirhodium(II) complex Rh2(tpa)4 (tpa = triphenylacetate) with the iodine(III) oxidant PhI(OPiv)2 is shown to promote the epoxidation of alkenes in the presence of 2 equivalents of water. The reaction can be applied to diversely substituted alkenes and the corresponding epoxides are isolated with yields of up to 90 %. A possible mechanism involves the dirhodium(II) complex as a Lewis acid species that would tune the oxidizing character of the iodine(III) reagent.

PYRROLOPYRAZINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Inversion of product selectivity in an enzyme-inspired metallosupramolecular tweezer catalyzed epoxidation reaction

This study describes a heteroligated, hemilabile PtII-P,S tweezer coordination complex that combines a chiral Jacobsen-Katsuki Mn III-salen epoxidation catalyst with an amidopyridine receptor, which leads to an inversion of the major epoxide product compared to catalysts without a recognition group. The Royal Society of Chemistry 2009.

AMIDE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula (I) or (II) or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, wherein Ar1, Ar2, R1, R3, p and n have the meaning defined in the claims. In particular, the present invention relates to more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.

Reaction of diphenylsulfonium methylide with carbonyl compounds in non-basic media

Diphenylsulfonium methylide was formed by fluoride-induced desilylation of diphenyl[(trimethylsilyl)methyl]sulfonium triflate with cesium fluoride in dimethyl sulfoxide and allowed to react with carbonyl compounds in situ to give oxiranes.

Oxidized diphenylheteroalkanes

Oxidized diphenylheteroalkanes of the formula I STR1 where R1 to R6 and A have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as cosmetic agents.