36101-18-5

Usage

Uses

Used in Cancer Treatment:
NSC24088 is used as an anticancer agent for its ability to inhibit the growth and proliferation of cancer cells by blocking the activity of heat shock protein 70 (HSP70). This leads to the induction of cell death in cancer cells and the inhibition of tumor growth in various types of cancer.
Used in Enhancing Chemotherapy and Radiotherapy Efficacy:
NSC24088 is used as an enhancer in cancer treatment to improve the efficacy of chemotherapy and radiotherapy. By targeting HSP70, it can potentially increase the sensitivity of cancer cells to these treatments, leading to better therapeutic outcomes for patients.

InChI:InChI=1/C14H10ClNO2/c15-13-9-5-1-3-7-11(9)14(16(17)18)12-8-4-2-6-10(12)13/h1-8,13-14H

Upstream product

• 120-12-7 anthracene 

Downstream Products

• 602-60-8 9-nitroanthracene 
• 434-85-5 bianthrone 
• 120-12-7 anthracene 

Relevant academic research and scientific papers

Synthesis of new chiral 1,3-aminoalcohols derived from levoglucosenone and their application in asymmetric alkylations

We have developed a simple procedure for the preparation of chiral 1,3-aminoalcohols using the biomass derivative levoglucosenone, as the chiral starting material. 1,3-aminoalcohols, bearing primary and tertiary amino groups, were tested as chiral catalysts in the asymmetric addition of diethyl zinc to benzaldehyde.

Asymmetric control in Diels-Alder cycloadditions of chiral 9-aminoanthracenes by relay of stereochemical information

Two approaches to the synthesis of chiral 9-amino anthracenes are described. The first, by nucleophilic addition of organolithium reagents to imines promoted by BF3·OEt2, unexpectedly provided stable aminoboranes as products. The second approach, using palladium catalysed cross coupling, was more successful for primary amines, and the key 9-(α-methylbenzylamino)anthracene subjected to cycloadditions with N-methyl maleimide and maleic anhydride. Excellent reactivity was achieved with good levels of diastereoselectivity, through a favourable combination of electrostatic and hydrogen bonding effects. Trial studies of the retro Diels-Alder reaction of these cycloadducts were also performed.