36112-55-7

Usage

Chemical class

Benzene and substituted derivatives

Physical state

Colorless liquid

Primary use

Research and development, pharmaceutical production, agrochemical production

Applications

Organic synthesis, chemical reactions

Importance

Building block for new compounds and materials

Pharmacological properties

Potential for drug discovery and medicinal chemistry.

Upstream product

• 36112-54-6 2-methoxy-6,7,8,9-tetrahydro-5H-benzocycloheptan-5-ol 
• 6500-64-7 5-(3'-methoxyphenyl)pentanoic acid 
• 6500-65-8 2-methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one 

Downstream Products

• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 3597-42-0 6-methoxy-1-naphthalaldehyde 
• 93640-67-6 1,2-cis-1-m-chlorobenzoyloxy-2-hydroxy-7-methoxybenzosuberan 
• 93640-67-6 1,2-trans-1-m-chlorobenzoyloxy-2-hydroxy-7-methoxybenzosuberan 

Relevant academic research and scientific papers

An Efficient Procedure for the Preparation of a Class of α-Carboxy-γ-Lactones, and Studies on their Transformation to α-Methylene Derivatives.

Attempted preparation of the bromohydrins (5a-b) gave interesting results.Ring opening of epoxides (1) and bromohydrins (5), the precursors of (1), with diethyl malonate anion under refluxing benzene has been shown to be the method of choice for the preparation of lactonic esters (acids)(3) in excellent yields.Methylenation of the lactonic acids provided the α-methylene-γ-lactones (4a-d).A possible pathway for the synthesis of the cis-lactones (22a-c) has also been investigated briefly.

Synthesis of 1-Hydroxy-2-(hydroxy/hydroxymethyl)benzosuberans as Potential Biodynamic Agents

Hydrogenation of 2-hydroxymethylenebenzosuber-1-one (3), prepared by formylation of benzosuber-1-one (1), gives 2-hydroxymethylbenzosuberan (6) whereas KBH4 reduction of 3 affords 1,2-cis-1-hydroxy-2-hydroxymethylbenzosuberan (4). 1,2-cis-1,2-Dihydroxyben