361145-78-0

Basic information

• Product Name: 3-(1H-1,2,3-benzotriazol-1-yl)-2-{2-[(2,5-dimethylphenyl)thio]ethyl}-1-isoindolinone
• Synonyms: 3-(1H-1,2,3-benzotriazol-1-yl)-2-{2-[(2,5-dimethylphenyl)thio]ethyl}-1-isoindolinone
• CAS NO: 361145-78-0
• Molecular Weight: 414.531
• Mol File: 361145-78-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(1H-1,2,3-benzotriazol-1-yl)-2-{2-[(2,5-dimethylphenyl)thio]ethyl}-1-isoindolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1H-1,2,3-benzotriazol-1-yl)-2-{2-[(2,5-dimethylphenyl)thio]ethyl}-1-isoindolinone(361145-78-0)
• EPA Substance Registry System: 3-(1H-1,2,3-benzotriazol-1-yl)-2-{2-[(2,5-dimethylphenyl)thio]ethyl}-1-isoindolinone(361145-78-0)

Safety Data

• Hazardous Substances Data: 361145-78-0(Hazardous Substances Data)

Upstream product

• 4001-61-0 2,5-dimethylthiophenol 
• 95-14-7 1,2,3-Benzotriazole 
• 56761-95-6 2-Aminoaethyl-2,5-dimethylphenyl-sulfid 
• 119-67-5 o-carboxybenzaldehyde 

Relevant articles and documents

Syntheses of 1,4-benzothiazepines and 1,4-benzoxazepines via cyclizations of 1-[2-arylthio(oxy)ethyl]-5-benzotriazolyl-2-pyrrolidinones and 3-benzotriazolyl-2-[2-arylthio(oxy)ethyl]-1-isoindolinones

1-[2-Arylthio(oxy)ethyl]-5-benzotriazolyl-2-pyrrolidinones 6a-e, 12 and 3-benzotriazolyl-2-[2-arylthio(oxy)ethyl]-1-isoindolinones 9a-f, 14 are readily available from reactions of benzotriazole (4), 2-(arylsulfanyl)ethylamines 3, or 2-phenoxyethylamine (11) with 2,5-dimethoxy-2,5-dihydrofuran (5) or 2-formylbenzoic acid (8). Lewis acid mediated cyclizations of 6 and 9 produced novel 1,4-benzothiazepines 7a-e and 10a-f, respectively. Cyclizations of 12 and 14 gave 1,4-benzoxazepines 13 and 15, respectively.