361186-13-2Relevant academic research and scientific papers
Intramolecular Heck reaction: A facile sequential one-pot synthesis of 1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridines
Bharath Kumar Reddy, Puchakayala,Ravi, Kanakaraju,Mahesh, Kukkamudi,Leelavathi, Panaganti
supporting information, p. 4039 - 4043 (2018/10/09)
A simple and convenient sequential one-pot synthesis of 1,2,3,4-tetrahydrobenzo[b][1,6] naphthyridines has been developed. The reductive amination of 2-chloro-3-formylquinolines with various amines in the presence of sodium borohydride provided the corresponding secondary amines in high yields. Further, a sequential one-pot reaction involving N-allylation and intramolecular Heck type 6-exo-trig cyclization was performed on the secondary amines to afford a range of desired 1,2,3,4-tetrahydrobenzo[b][1,6]-naphthyridine derivatives in good to high yields.
Synthesis of some new 4-thiazolidinones as biologically potent agents
Datta, Neela J.,Khunt, Ranjan C.,Parikh
, p. 433 - 435 (2007/10/03)
Thiazolidin 3a-o, 4a-o have been synthesised by the cyclodensation of thioglycolic acid / thiolactic acid with N-aryl-2-chloroquinolin-3-yl-azomethine 2a-o which in turn have been prepared by the action of amines on 2-chloroquinolin-3-carboxaldehyde 1. The structure of the compounds 2a-o, 3a-o and 4a-o have been confirmed from elemental analyses, IR, IH NMR and mass spectral data. All the products have been screened for their antimicrobial activity against several microbes.
