361192-82-7Relevant academic research and scientific papers
A stereoselective approach for the synthesis of α-sialosides
de Meo,Demchenko,Boons
, p. 5490 - 5497 (2007/10/03)
A highly efficient synthesis of the human melanoma associated antigen GD3 derivative has been described. A key feature of the synthetic approach was the use of sialyl donors that were protected with a C-5 trifiuoroacetamide moiety. These sialyl donors gave high yields and excellent α-anomeric selectivities in direct glycosylations with a wide variety of glycosyl acceptors ranging from C-8 hydroxyls of sialic acids and C-3 hydroxyls of galactosides to reactive primary alcohols.
