3612-14-4

Basic information

• Product Name: 1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-4-one
• Synonyms: 1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-piperidin-4-one
• CAS NO: 3612-14-4
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.3321
• Mol File: 3612-14-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 396.1°C at 760 mmHg
• Flash Point: 193.4°C
• Density: 1.095g/cm³
• Vapor Pressure: 1.75E-06mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-4-one(3612-14-4)
• EPA Substance Registry System: 1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-4-one(3612-14-4)

Safety Data

• Hazardous Substances Data: 3612-14-4(Hazardous Substances Data)

Usage

Chemical structure

Piperidinone derivative with a piperidine ring and a phenethyl group with two methoxy substituents

Pharmaceutical properties

Exhibits analgesic and anticonvulsant activities

Potential applications

Treatment of neurodegenerative diseases

Research status

Shown promise in preclinical studies

Field of application

Medicine and pharmacology

Upstream product

• 40173-90-8 3,4-dimethoxyphenethyl bromide 
• 177-11-7 4,4-ethylenedioxy-piperidine 

Downstream Products

• 1071139-10-0 C₁₅H₁₉NO₃ 
• 134826-28-1 1-<2-(3,4-dimethoxyphenyl)ethyl>-4-benzoylhydroxypiperidine hydrochloride 
• 134826-27-0 1-<2-(3,4-dimethoxyphenyl)ethyl>-4-propionylhydroxypiperidine hydrochloride 
• 134826-26-9 1-<2-(3,4-dimethoxyphenyl)ethyl>-4-acetohydroxypiperidine hydrochloride 
• 73735-45-2 (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(3,4-dimethoxy-phenyl)-ethyl]-piperidin-4-yl}-amine 
• 134826-25-8 1-<2-(3,4-dimethoxyphenyl)ethyl>-4-hydroxypiperidine 
• 22350-18-1 1-(3,4-dimethoxy-phenethyl)-piperidin-4-ylamine 

Relevant articles and documents

Fentanyl family at the mu-opioid receptor: Uniform assessment of binding and computational analysis

Interactions of 21 fentanyl derivatives with μ-opioid receptor (μOR) were studied using experimental and theoretical methods. Their binding to μOR was assessed with radioligand competitive binding assay. A uniform set of binding affinity data contains val

New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines

The synthesis of a series N-(4-piperidinyl)-1H-benzimidazol-2-amines and the preliminary evaluation of their in vitro and in vivo antihistaminic activity are described. Cyclodesulfurization of (2-aminophenyl) thioureas with mercury(II) oxide resulted in 2-aminobenzimidazole intermediates, which were monoalkylated on the endo-nitrogen atom. After deprotection of the piperideine nitrogen atom with 48% aqueous hydrobromic acid solution, the title compounds were obtained by three different methods, viz. alkylation, reductive amination, or oxirane ring-opening reactions. The in vivo antihistaminic activity was evaluated by the compound 48/80 induced lethality test in rats and histamine-induced lethality test in guinea pigs after oral and/or subcutaneous administration. The duration of action, for a selected number of compounds, was studied in the guinea pig. The phenylethyl derivatives showed the most potent antihistamine properties after oral administration in both animal species.