3612-79-1Relevant academic research and scientific papers
Binuclear dichlorido(η6-p-cymene)ruthenium(II) complexes with bis(nicotinate)- And bis (isonicotinate)-polyethylene glycol ester ligands
Eichhorn, Thomas,Hey-Hawkins, Evamarie,Maksimovi-Ivani, Danijela,Moji, Marija,Schmidt, Jürgen,Mijatovi, Sanja,Schmidt, Harry,Kaluderovi, Goran N.
, p. 20 - 25 (2015)
Neutral binuclear ruthenium complexes 1-8 of the general formula [{RuCl2(η6-p-cym)}2 μ-(N∩N)] (N∩N=bis(nicotinate)- and bis (isonicotinate)-polyethylene glycol esters: (3-py)COO(CH2CH2O)nCO(3-py) and (4-py)COO(CH2CH2O)nCO(4-py), n =1-4), as well as mononuclear [RuCl2(η6-p-cym)((3-py)COO(CH2CH2OCH3)-κN)], complex 9, were synthesized and characterized using elemental analysis and electrospray ionization high-resolution mass spectrometry, infrared, 1H NMR and 13C NMR spectroscopies. Stability of the binuclear complexes in the presence of dimethylsulfoxide was studied. Furthermore, formation of a cationic complex containing bridging pyridine-based bidentate ligand was monitored using 1H NMR spectroscopy. Ligand precursors, polyethylene glycol esters of nicotinic (L1·2HCl-L4·2HCl and L9·HCl) and isonicotinic acid dihydrochlorides (L5·2HCl-L8·2HCl), binuclear ruthenium(II) complexes 1-8 and mononuclear complex 9 were tested for in vitro cytotoxicity against 518A2 (melanoma), 8505C (anaplastic thyroid cancer), A253 (head and neck tumour), MCF-7 (breast tumour) and SW480 (colon carcinoma) cell lines.
