361345-65-5Relevant academic research and scientific papers
Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: Sar and in vivo characterization
Basarab, Gregory S.,Brassil, Patrick,Doig, Peter,Galullo, Vincent,Haimes, Howard B.,Kern, Gunther,Kutschke, Amy,McNulty, John,Schuck, Virna J. A.,Stone, Gregory,Gowravaram, Madhusudhan
, p. 9078 - 9095 (2015/03/14)
The compounds described herein with a spirocyclic architecture fused to a benzisoxazole ring represent a new class of antibacterial agents that operate by inhibition of DNA gyrase as corroborated in an enzyme assay and by the inhibition of precursor thymi
FUSED, SPIROCYCLIC HETEROAROMATIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS
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Page/Page column 100, (2010/04/30)
The present invention relates to compounds of Formula (I); to pharmaceutical1y acceptable salts thereof, to methods of using them to treat bacterial infections, and to methods for their preparation
Beyond the MEK-pocket: Can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
Tecle, Haile,Shao, Jianxing,Li, Yanhong,Kothe, Michael,Kazmirski, Steven,Penzotti, Julie,Ding, Yuan-Hua,Ohren, Jeffrey,Moshinsky, Deb,Coli, Rocco,Jhawar, Nidhi,Bora, Emilia,Jacques-O'Hagan, Suzanne,Wu, Joe
scheme or table, p. 226 - 229 (2009/05/26)
An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket
5-Amide substituted diarylamines as mex inhibitors
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Page 13; 6, (2010/02/03)
Diarylanines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK
