361364-19-4

Basic information

• Product Name: 2-(4-fluorophenyl)-2,3-dihydrophthalazine-1,4-dione
• Synonyms: 2-(4-fluorophenyl)-2,3-dihydrophthalazine-1,4-dione
• CAS NO: 361364-19-4
• Molecular Weight: 256.236
• Mol File: 361364-19-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-2,3-dihydrophthalazine-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-2,3-dihydrophthalazine-1,4-dione(361364-19-4)
• EPA Substance Registry System: 2-(4-fluorophenyl)-2,3-dihydrophthalazine-1,4-dione(361364-19-4)

Safety Data

• Hazardous Substances Data: 361364-19-4(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 371-14-2 4-fluorophenylhydrazine 

Downstream Products

• 1259300-57-6 C₁₄H₈BrFN₂O 
• 99682-90-3 6-fluoro-2,4-diphenylquinazoline 

Relevant articles and documents

Ru(II)-Catalyzed C-H Hydroxyalkylation and Mitsunobu Cyclization of N-Aryl Phthalazinones

Ruthenium(II)-catalyzed C(sp2)-H functionalization of N-Aryl phthalazinones with a range of aldehydes and activated ketone is described. Initial formation of hydroxyalkylated phthalazinones and subsequent Mitsunobu cyclization provided facile access to biologically relevant indazolophthalazinones. The utility of this method is highlighted by synthetic transformations into a series of potentially bioactive scaffolds.

Ru(II)-Catalyzed C-H Activation and Annulation Reaction via Carbon-Carbon Triple Bond Cleavage

An unprecedented Ru(II)-catalyzed C-H activation and annulation reaction, which proceeds via C-C triple bond cleavage, is reported. This reaction of 2-phenyldihydrophthalazinediones with alkynes, which works most efficiently in the presence of bidented ligand 1,3-bis(diphenylphosphino)propane, affords good yields of substituted quinazolines.

Synthesis of cinnolines via Rh(III)-catalysed dehydrogenative C-H/N-H functionalization: Aggregation induced emission and cell imaging

Rhodium catalysed dehydrogenative C-H/N-H functionalization was developed to construct phthalazino[2,3-a]-/indazolo[1,2-a]cinnolines by reacting N-phenyl phthalazine/indazole with alkynes. The synthesized compounds exhibit prominent fluorescence properties in solid and aggregation states. Their application in cell imaging was investigated using various cancer cell lines.