361385-16-2

Upstream product

• 3068-34-6 Acetic acid (2R,3S,4R,5R,6R)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-chloro-tetrahydro-pyran-4-yl ester 
• 97-51-8 5-Nitrosalicylaldehyde 
• 361385-15-1 Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-(2-formyl-4-nitro-phenoxy)-tetrahydro-pyran-4-yl ester 

Downstream Products

• 361385-17-3 Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-tert-butoxycarbonylamino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester 
• 361385-18-4 Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-amino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester 

Relevant academic research and scientific papers

INTRACELLULAR SUBSTANCE TRANSPORT SYSTEM AND USE THEREOF

The present invention pertains to a complex including nanoparticles and, carried on the surface of the nanoparticles, a lysosomal enzyme inhibitor or kinase inhibitor shown by general formula (A) and a phospholipid mimetic substance shown by general formula (B). In general formula (A), n1 is an integer of 2-30, n2 is an integer of 2-30, the -S- terminal is a nanoparticle-carrying site, and R10 is a suicide substrate site or a kinase inhibition site. In general formula (B), n3 is an integer in the range of 2-30, and the -S- terminal is a nanoparticle-carrying site. The present invention provides a versatile system capable of efficiently delivering a drug to endolysosomes and allowing the drug to function at a low concentration on lysosomal enzymes, and an anticancer agent in which this system is used.

A mechanism-based affinity-labeling agent for possible use in isolating N-acetylglucosaminidase

We have prepared several mechanism-based affinity-labeling agents for possible use in isolating N-acetylglucosaminidase, in which an N-acetylglucosamine is linked to an o-monofluoro- or difluoro-methyl phenoxy glycoside with or without a cleavable disulfide group in the tether to biotin.